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- ISSN: 1568-010X
- E-ISSN: 1568-010X
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Macrophage-Derived IL-18 Targeting for the Treatment of Crohn's Disease
- Source: Current Drug Targets - Inflammation & Allergy, Volume 2, Issue 2, Jun 2003, p. 131 - 136
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- 01 Jun 2003
Abstract
Crohn's disease is an inflammatory bowel disease associated with several changes in the immune system, including an increased number of infiltrating macrophages. These macrophages release a variety of proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), macrophage infiltrating factor (MIF), interleukin (IL)-6, IL-12 and IL-18, which are critically involved in the onset and the development of Crohn's disease. We here focus on the role of macrophages, especially macrophagederived IL-18 in both patients with Crohn's disease and a murine model of Crohn's disease.
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