Cholesterol and Apoe: A Target for Alzheimer's Disease Therapeutics

Daniela Fenili; JoAnne McLaurin

doi:10.2174/156800705774322085

ISSN: 1568-007X
E-ISSN: 1568-007X

Cholesterol and Apoe: A Target for Alzheimer's Disease Therapeutics
Authors: Daniela Fenili¹ and JoAnne McLaurin²
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¹ University of Toronto, 6 Queen's Park Crescent West, Toronto, ON M5S 3H2, Canada. ² University of Toronto, 6 Queen's Park Crescent West, Toronto, ON M5S 3H2, Canada.
Source: Current Drug Targets-CNS & Neurological Disorders, Volume 4, Issue 5, Oct 2005, p. 553 - 567
DOI: https://doi.org/10.2174/156800705774322085
- Available online: 01 Oct 2005

Abstract

Alzheimer's disease (AD) is a debilitating disease that affects many people. In order to reduce the number of people diagnosed with this disease, drug strategies need to be implemented that target early steps in disease pathogenesis. Elevated cholesterol levels and presence of the apolipoprotein E 4 allele increase AD risk. How these two factors may contribute to AD pathogenesis and some therapeutic strategies for alleviating AD risk will be discussed.

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2005-10-01

2025-09-06

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Article Type: Review Article

Keyword(s): alzheimers disease; apoe; cholesterol; fibrillogenesis; membrane fluidity; statins

Cholesterol and Apoe: A Target for Alzheimer's Disease Therapeutics

Abstract

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