Neurodegenerative Pathways in Parkinson's Disease: Therapeutic Strategies

S. M. Cardoso; P. I. Moreira; P. Agostinho; C. Pereira; C. R. Oliveira

doi:10.2174/1568007054546072

ISSN: 1568-007X
E-ISSN: 1568-007X

Neurodegenerative Pathways in Parkinson's Disease: Therapeutic Strategies
Authors: S. M. Cardoso¹, P. I. Moreira², P. Agostinho³, C. Pereira⁴ and C. R. Oliveira⁵
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¹ Center for Neuroscience and Cell Biology and Institute of Biochemistry, Faculty of Medicine of Coimbra, University of Coimbra, 3004-504 Coimbra, Portugal; ² Center for Neuroscience and Cell Biology and Institute of Biochemistry, Faculty of Medicine of Coimbra, University of Coimbra, 3004-504 Coimbra, Portugal; ³ Center for Neuroscience and Cell Biology and Institute of Biochemistry, Faculty of Medicine of Coimbra, University of Coimbra, 3004-504 Coimbra, Portugal; ⁴ Center for Neuroscience and Cell Biology and Institute of Biochemistry, Faculty of Medicine of Coimbra, University of Coimbra, 3004-504 Coimbra, Portugal; ⁵ Center for Neuroscience and Cell Biology and Institute of Biochemistry, Faculty of Medicine of Coimbra, University of Coimbra, 3004-504 Coimbra, Portugal;
Source: Current Drug Targets-CNS & Neurological Disorders, Volume 4, Issue 4, Aug 2005, p. 405 - 419
DOI: https://doi.org/10.2174/1568007054546072
- Available online: 01 Aug 2005

Abstract

Parkinson's disease (PD), considered one of the major neurological disorders, is characterized by the loss of dopaminergic neurons in the pars compacta of the substantia nigra and by the presence of intraneuronal cytoplasmic inclusions called Lewy bodies. The causes for degeneration of PD neurons remain unclear, however, recent findings contributed to clarify this issue. This review will discuss the current understanding of the mechanisms underlying Parkinson's disease pathogenesis, focusing on the current and potential therapeutic strategies for human treatment.

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2005-08-01

2025-10-31

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Article Type: Review Article

Keyword(s): cell death; mitochondria; neuroinflammation; neuronal circuits; oxidative stress; proteasome; synuclein; therapeutics

Neurodegenerative Pathways in Parkinson's Disease: Therapeutic Strategies

Abstract

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