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2000
Volume 13, Issue 13
  • ISSN: 1389-4501
  • E-ISSN: 1873-5592

Abstract

Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Discovery of novel therapeutic opportunities for EOC is important for the improvement of clinical outcome of the patients. Emerging evidence is suggesting that epithelial-mesenchymal transition (EMT) plays a crucial role in the aggressiveness in EOC including increasing migration and invasion ability, contributing to chemoresistance and cancer stem cell populations. Targeting EMT in EOC thus offers an attractive therapeutic option.

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/content/journals/cdt/10.2174/138945012803530044
2012-12-01
2025-09-16

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  • Article Type:     Research Article
Keyword(s): chemoresistance; cnidarian species; Drosophila embryos; embryonic epithelia; Epithelial-mesenchymal transition; motile mesenchymal cells; ovarian cancer; Snail; tumor cells; Twist

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