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2000
Volume 24, Issue 3
  • ISSN: 1389-4501
  • E-ISSN: 1873-5592

Abstract

Background: Epilepsy is a neurological disease affected by an imbalance of inhibitory and excitatory signaling in the brain. Introduction: In this disease, the targets are active in pathophysiology and thus can be used as a focus for pharmacological treatment. Methods: Several studies demonstrated the antiepileptic effect of drugs acting on the following targets: N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, voltage-gated calcium channel (Cav), Gamma aminobutyric acid transporter type 1 (GAT1), voltage-gated sodium channels (Nav), voltage-gated potassium channel of the Q subfamily (KCNQ) and Gamma aminobutyric acid type A (GABAA) receiver. Results: These studies highlight the importance of molecular docking. Conclusion: Quantitative Structure-Activity Relationship (QSAR) and computer aided drug design (CADD) in predicting of possible pharmacological activities of these targets.

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/content/journals/cdt/10.2174/1389450123666220927103715
2023-02-01
2024-11-12
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/content/journals/cdt/10.2174/1389450123666220927103715
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  • Article Type:
    Review Article
Keyword(s): AMPA; Cav; GAT1; KCNQ; Molecular docking; Nav e GABAA; NMDA
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