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Epileptic Targets and Drugs: A Mini-Review
- Source: Current Drug Targets, Volume 24, Issue 3, Feb 2023, p. 212 - 224
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- 01 Feb 2023
Abstract
Background: Epilepsy is a neurological disease affected by an imbalance of inhibitory and excitatory signaling in the brain. Introduction: In this disease, the targets are active in pathophysiology and thus can be used as a focus for pharmacological treatment. Methods: Several studies demonstrated the antiepileptic effect of drugs acting on the following targets: N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, voltage-gated calcium channel (Cav), Gamma aminobutyric acid transporter type 1 (GAT1), voltage-gated sodium channels (Nav), voltage-gated potassium channel of the Q subfamily (KCNQ) and Gamma aminobutyric acid type A (GABAA) receiver. Results: These studies highlight the importance of molecular docking. Conclusion: Quantitative Structure-Activity Relationship (QSAR) and computer aided drug design (CADD) in predicting of possible pharmacological activities of these targets.