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- ISSN: 1389-4501
- E-ISSN: 1873-5592
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PDGF-D Signaling: A Novel Target in Cancer Therapy
- Source: Current Drug Targets, Volume 10, Issue 1, Jan 2009, p. 38 - 41
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- 01 Jan 2009
Abstract
Platelet-derived growth factor-D (PDGF-D) is a newly recognized growth factor that can regulate many cellular processes, including cell proliferation, transformation, invasion, and angiogenesis by specifically binding to and activating its cognate receptor PDGFR-β. The functions of PDGF-D in human cancer progression are largely unknown. We discuss here the role of PDGF-D signaling pathway in cancer and how its deregulation is involved in tumor development and progression to metastatic disease.
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