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image of The Emerging Landscape of LINC01123 in Cancer: Roles, Mechanisms, and Clinical Significance

Abstract

Introduction

Long intergenic non-coding RNA 01123 (LINC01123) is a lncRNA located on the human chromosome 2q13. It is upregulated in various cancers and has been identified as an oncogene. Its expression is associated with the risk and poor prognosis of multiple cancers.

Methods

A systematic literature search was conducted in PubMed, Web of Science, and Google Scholar databases using “LINC01123” as the search term. The retrieved studies were reviewed to analyze the expression patterns, oncogenic mechanisms, and clinical significance of LINC01123 in cancers.

Results

LINC01123 is activated by transcription factors such as c-Myc, ZEB1, and FOXC1. It promotes cancer progression, metastasis, and drug resistance by acting as a “molecular sponge” for miRNAs, activating signaling pathways, or interacting with proteins. Its upregulation correlates with adverse clinicopathological features and poor prognosis in multiple cancers.

Discussion

The findings suggest that LINC01123 plays a multifaceted role in cancer biology. Its ability to regulate gene expression through various mechanisms highlights its potential as both a prognostic biomarker and a therapeutic target. However, further research is needed to elucidate its mechanisms fully and to explore its clinical applications across different cancer types.

Conclusion

LINC01123 has potential as a novel prognostic biomarker and therapeutic target for cancer. Further research is needed to elucidate its mechanisms and clinical applications fully.

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2025-09-11
2025-09-14

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The Emerging Landscape of LINC01123 in Cancer: Roles, Mechanisms, and Clinical Significance
Bentham Science Publishers ; https://doi.org/10.2174/0113894501398484250903074131
/content/journals/cdt/10.2174/0113894501398484250903074131
/content/journals/cdt/10.2174/0113894501398484250903074131
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  • Article Type:     Review Article
Keywords: LncRNA ; LINC01123 ; therapeutic target ; biomarker ; Cancer ; molecular mechanism

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