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2000
Volume 26, Issue 13
  • ISSN: 1389-4501
  • E-ISSN: 1873-5592

Abstract

Background

Gut-peptide hormones are crucial regulators of various physiological processes, including metabolism, digestion, behavior, and homeostasis. In a widely used model organism, a diverse range of gut-peptide hormones governs gut-brain communication, influencing food intake, energy balance, circadian rhythms, stress responses, and aging.

Objective

This review summarizes recent studies on gut-peptide hormones in , focusing on their mechanisms of action, interactions with other signaling pathways, and their relevance to human orthologs.

Methods

The PubMed database was searched for studies on gut-peptide hormones in published in the past decade.

Results

The functions of gut-peptide hormones were reviewed, including DH31, Bursicon (Burs), Tachykinins (Tks), Hedgehog (Hh), Pigment-dispersing factor (PDF), Neuropeptide F (NPF), Short neuropeptide F (sNPF), Allatostatins (ASTs), CCHamides (CCHa), and Limostatin (Lst). These hormones regulate key physiological processes such as digestion, energy homeostasis, and metabolism through conserved pathways.

Conclusion

gut-peptide hormones are fundamental regulators of health and disease. They are conducive to exploring conserved mechanisms for developing treatments against human metabolic and aging disorders.

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Gut-Brain Dialogues in Fruit Fly (Drosophila melanogaster): How Peptide Hormones Bridge Metabolism, Longevity, and Behavioral Adaptation
Curr Drug Targets 26, 954 (2025); https://doi.org/10.2174/0113894501397622250801062050
/content/journals/cdt/10.2174/0113894501397622250801062050
/content/journals/cdt/10.2174/0113894501397622250801062050
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  • Article Type:     Review Article
Keyword(s): cholecystokinin, nutrient metabolism; Drosophila; growth and development; Gut-peptide hormones; intestinal homeostasis

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