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Introduction: Pregabalin is a gamma-aminobutyric acid (GABA) analogue approved for the treatment of neuropathic pain, partial seizure and generalized anxiety disorder. As a GABA analogue, there is a raising concern regarding the abuse potential of this drug. Case: We present a first case of pregabalin dependence in a 26-year-old woman without a previous history of illicit drug abuse. Discussion: Physician should be aware about the addictive potential of pregabalin even in patients without a previous history of substance abuse.