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2000
Volume 20, Issue 3
  • ISSN: 1574-8863
  • E-ISSN: 2212-3911

Abstract

Introduction

It is essential to exclude other causes, such as autoimmune diseases and bacterial infections, before attributing cutaneous/systemic vasculitis to drug use.

Case Study

This report discusses the case of a young man who developed multi-organ failure and cutaneous vasculitis following the use of antifungal medications (terbinafine and itraconazole) for dermatophyte infections. Tests for autoimmune diseases and infections were negative. Given his drug history and a skin biopsy indicating leukocytoclastic vasculitis, it was inferred that the vasculitis was likely drug-induced. Despite treatment with steroids, intravenous immunoglobulins, and plasmapheresis, the patient did not survive, possibly due to delayed diagnosis and treatment.

Conclusion

In community practice, Drug-induced Vasculitis (DIV) is frequently overlooked. When patients present with skin rash, fever, and multi-organ dysfunction, DIV should be considered, particularly in the context of recent drug use. Over-the-counter antifungals, like terbinafine or itraconazole, can cause DIV and may be fatal if not promptly diagnosed and treated.

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2024-09-19
2025-09-01

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Possible Terbinafine and/or Itraconazole Induced Vasculitis - A Case Study
Curr Drug Saf 20, 377 (2025); https://doi.org/10.2174/0115748863327130240909044620
/content/journals/cds/10.2174/0115748863327130240909044620
/content/journals/cds/10.2174/0115748863327130240909044620
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  • Article Type:     Case Report
Keyword(s): Adverse drug reaction; antifungals; cutaneous vasculitis; leukocytoclastic vasculitis; over the counter drugs; temporal association

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