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image of Starch Biopolymer Functionalized with Ipomoea batatas Extract: A Natural System for Bioactive Delivery in Type II Diabetes

Abstract

Introduction

Type 2 diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia. Natural compounds derived from plants, such as , have shown therapeutic potential for its treatment.

Methods

A starch-based biopolymer was developed and functionalized with a methanolic extract of (IBM). Its physicochemical properties, such as swelling capacity, encapsulation efficiency, and extract release, were evaluated. tests were conducted on diabetic using two administration routes: immersion and oral delivery.

Results

The biopolymer exhibited a swelling capacity of 333.03% and an encapsulation efficiency of 47.78%. In the zebrafish model, significant reductions in glucose, triglycerides, and cholesterol levels were observed, along with inhibition of advanced glycation end products (AGEs) formation in groups treated with IBM and BP-IBM.

Discussion

The results suggest that the biopolymer preserves the chemical integrity of the extract and improves its bioavailability, enabling a significant therapeutic effect. The dual administration routes provide flexibility and demonstrate the efficacy of the delivery system.

Conclusion

The starch-based system functionalized with extract proved to be a promising and non-toxic platform for the delivery of bioactive metabolites in type 2 diabetes models, with potential for future therapeutic applications.

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2025-08-12
2025-09-25

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/content/journals/cdd/10.2174/0115672018385495250801091747
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Starch Biopolymer Functionalized with Ipomoea batatas Extract: A Natural System for Bioactive Delivery in Type II Diabetes
Bentham Science Publishers ; https://doi.org/10.2174/0115672018385495250801091747
/content/journals/cdd/10.2174/0115672018385495250801091747
/content/journals/cdd/10.2174/0115672018385495250801091747
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  • Article Type:     Research Article
Keywords: advanced glycation end products ; Type 2 diabetes mellitus ; Ipomoea batatas ; Danio rerio ; biopolymers ; therapeutic

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