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Abstract

Introduction

L. seed oil, L. seed oil, and the L. oil macerates of (Roth) G. flowers and L. flowers were used for the preparation of topical wound-healing ointments.

Methods

The ointments basically were prepared by hot-melt blending method and subjected to rheological tests and texture profile analysis. After characterization of characterization studies, a scratch assay was conducted to evaluate the efficacy of ointment formulations. Ultimately, the optimized formulations underwent further testing on an burn wound model in mice.

Results

Measured viscosity values were F1:382.98 Pa.s and F2:2562.3 Pa.s, respectively, and both of the formulations created an easy-to-apply, soft, thin adhesive film layer. The fast wound closure was observed with F1 formulation, and when applied at different doses of 100 µL, 200 µL, and 400 µL, the 200 µL concentration of F1 formulation was able to heal the wound totally (100%) at 48th hour.

Discussion

The F1 formulation presented lower viscosity than the F2; the increase in the white petrolatum concentration increased the initial viscosity as expected. F1 formulation had higher phyto-actives and and lower petrolatum in comparison to F2. The wound healing effects of both the formulations were synergistic due to their phytoactives content. In studies, the F1 ointment exhibited faster re-epithelialization with less inflammation compared to the burn control group.

Conclusion

The best formulation included oils of , and at a total concentration of 16%, exhibiting appropriate preadability and successful healing property. Additional research needs to be carried out to shed light on the mechanism underlying the formulation's healing capabilities.

© 2026 The Author(s). Published by Bentham Science Publishers.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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2026-01-08
2026-02-15

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The Influence of Phyto-Active Incorporated Topical Formulations on Cell Migration in Scratch Assays and In vivo Wound Model in Mice
Bentham Science Publishers ; https://doi.org/10.2174/0115672018381444251009112958
/content/journals/cdd/10.2174/0115672018381444251009112958
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  • Article Type:     Research Article
Keywords: rheology ; wound healing ; scratch assay ; Phytomedicine ; texture analysis ; in vivo burn model ; histological examinations

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