Skip to content
2000
image of Nano Biomaterials in Drug Delivery and Tissue Engineering

Abstract

The integration of nanotechnology with biomaterials has opened new avenues in drug delivery and tissue engineering, enhancing therapeutic efficacy and patient outcomes. Nano-sized biomaterials (1-100 nm) demonstrate unique properties that improve drug targeting, reduce side effects, and facilitate tissue regeneration. This review highlights the multifunctional applications of nanoparticles, particularly selenium nanoparticles, in cancer therapy and regenerative medicine. By optimizing interactions with biological systems, these advanced materials are poised to revolutionize treatment protocols, offering targeted therapies that combine diagnostics and therapeutics. The potential of nanobiotechnology in clinical applications underscores its critical role in advancing personalized medicine.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cdd/10.2174/0115672018378493251006062026
2025-10-28
2026-02-25

  • From This Site

    /content/journals/cdd/10.2174/0115672018378493251006062026
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. Karagkiozaki V. Karagiannidis P.G. Kalfagiannis N. Kavatzikidou P. Patsalas P. Georgiou D. Logothetidis S. Novel nanostructured biomaterials: Implications for coronary stent thrombosis. Int. J. Nanomedicine 2012 7 6063 6076 23269867
    [Google Scholar]
  2. Elmowafy E. Abdal-Hay A. Skouras A. Tiboni M. Casettari L. Guarino V. Polyhydroxyalkanoate (PHA): Applications in drug delivery and tissue engineering. Expert Rev. Med. Devices 2019 16 6 467 482 10.1080/17434440.2019.1615439 31058550
    [Google Scholar]
  3. Tang Z. He C. Tian H. Ding J. Hsiao B.S. Chu B. Chen X. Polymeric nanostructured materials for biomedical applications. Prog. Polym. Sci. 2016 60 86 128 10.1016/j.progpolymsci.2016.05.005
    [Google Scholar]
  4. Melchor-Martínez E.M. Torres Castillo N.E. Macias-Garbett R. Lucero-Saucedo S.L. Parra-Saldívar R. Sosa-Hernández J.E. Modern world applications for nano-bio materials: Tissue engineering and COVID-19. Front. Bioeng. Biotechnol. 2021 9 597958 10.3389/fbioe.2021.597958 34055754
    [Google Scholar]
  5. Luzi F. Puglia D. Torre L. Natural fiber biodegradable composites and nanocomposites. In: Biomass, Biopolymer-Based Materials, and Bioenergy. Woodhead Publishing 2019 179 201 10.1016/B978‑0‑08‑102426‑3.00010‑2
    [Google Scholar]
  6. Razavi M. Bio-based nanostructured materials” Nanobiomaterials. Woodhead Publishing 2018 17 39
    [Google Scholar]
  7. Ma W. Zhan Y. Zhang Y. Mao C. Xie X. Lin Y. The biological applications of DNA nanomaterials: Current challenges and future directions. Signal Transduct. Target. Ther. 2021 6 1 351 10.1038/s41392‑021‑00727‑9 34620843
    [Google Scholar]
  8. Li M. Du C. Guo N. Teng Y. Meng X. Sun H. Li S. Yu P. Galons H. Composition design and medical application of liposomes. Eur. J. Med. Chem. 2019 164 640 653 10.1016/j.ejmech.2019.01.007 30640028
    [Google Scholar]
  9. Sun Y. Dai C. Yin M. Lu J. Hu H. Chen D. Hepatocellular carcinoma-targeted effect of configurations and groups of glycyrrhetinic acid by evaluation of its derivative-modified liposomes. Int. J. Nanomedicine 2018 13 1621 1632 10.2147/IJN.S153944 29588589
    [Google Scholar]
  10. Fan Y.P. Liao J.Z. Lu Y.Q. Tian D.A. Ye F. Zhao P.X. Xiang G.Y. Tang W.X. He X.X. MiR-375 and doxorubicin co-delivered by liposomes for combination therapy of hepatocellular carcinoma. Mol. Ther. Nucleic Acids 2017 7 181 189 10.1016/j.omtn.2017.03.010 28624193
    [Google Scholar]
  11. He Q. He X. Deng B. Shi C. Lin L. Liu P. Yang Z. Yang S. Xu Z. Sorafenib and indocyanine green co-loaded in photothermally sensitive liposomes for diagnosis and treatment of advanced hepatocellular carcinoma. J. Mater. Chem. B Mater. Biol. Med. 2018 6 36 5823 5834 10.1039/C8TB01641K 32254989
    [Google Scholar]
  12. Abu Lila A.S. Ishida T. Liposomal delivery systems: Design optimization and current applications. Biol. Pharm. Bull. 2017 40 1 1 10 10.1248/bpb.b16‑00624 28049940
    [Google Scholar]
  13. Xu Y. Zheng Y. Wu L. Zhu X. Zhang Z. Huang Y. Novel solid lipid nanoparticle with endosomal escape function for oral delivery of insulin. ACS Appl. Mater. Interfaces 2018 10 11 9315 9324 10.1021/acsami.8b00507 29484890
    [Google Scholar]
  14. Subhan M.A. Torchilin V.P. Efficient nanocarriers of siRNA therapeutics for cancer treatment. Transl. Res. 2019 214 62 91 10.1016/j.trsl.2019.07.006 31369717
    [Google Scholar]
  15. Wang G. Wu B. Li Q. Chen S. Jin X. Liu Y. Zhou Z. Shen Y. Huang P. Active transportation of liposome enhances tumor accumulation, penetration, and therapeutic efficacy. Small 2020 16 44 2004172 10.1002/smll.202004172 33030305
    [Google Scholar]
  16. Cheng X. Gao J. Ding Y. Lu Y. Wei Q. Cui D. Fan J. Li X. Zhu E. Lu Y. Wu Q. Li L. Huang W. Multi‐functional liposome: A powerful theranostic nano‐platform enhancing photodynamic therapy. Adv. Sci. 2021 8 16 2100876 10.1002/advs.202100876 34085415
    [Google Scholar]
  17. Rommasi F. Esfandiari N. Liposomal nanomedicine: Applications for drug delivery in cancer therapy. Nanoscale Res. Lett. 2021 16 1 95 10.1186/s11671‑021‑03553‑8 34032937
    [Google Scholar]
  18. Antoniou A.I. Giofrè S. Seneci P. Passarella D. Pellegrino S. Stimulus-responsive liposomes for biomedical applications. Drug Discov. Today 2021 26 8 1794 1824 10.1016/j.drudis.2021.05.010 34058372
    [Google Scholar]
  19. Devulapally R. Foygel K. Sekar T.V. Willmann J.K. Paulmurugan R. Gemcitabine and antisense-microRNA co-encapsulated PLGA–PEG polymer nanoparticles for hepatocellular carcinoma therapy. ACS Appl. Mater. Interfaces 2016 8 49 33412 33422 10.1021/acsami.6b08153 27960411
    [Google Scholar]
  20. Özenler S. Yucel M. Tüncel Ö. Kaya H. Özçelik S. Yildiz U.H. Single chain cationic polymer dot as a fluorescent probe for cell imaging and selective determination of hepatocellular carcinoma cells. Anal. Chem. 2019 91 16 10357 10360 10.1021/acs.analchem.9b02300 31334629
    [Google Scholar]
  21. Wang H. Sun S. Zhang Y. Wang J. Zhang S. Yao X. Chen L. Gao Z. Xie B. Improved drug targeting to liver tumor by sorafenib-loaded folate-decorated bovine serum albumin nanoparticles. Drug Deliv. 2019 26 1 89 97 10.1080/10717544.2018.1561766 30744448
    [Google Scholar]
  22. Turato C. Balasso A. Carloni V. Tiribelli C. Mastrotto F. Mazzocca A. Pontisso P. New molecular targets for functionalized nanosized drug delivery systems in personalized therapy for hepatocellular carcinoma. J. Control. Release 2017 268 184 197 10.1016/j.jconrel.2017.10.027 29051062
    [Google Scholar]
  23. Kang J.H. Toita R. Murata M. Liver cell-targeted delivery of therapeutic molecules. Crit. Rev. Biotechnol. 2016 36 1 132 143 10.3109/07388551.2014.930017 25025274
    [Google Scholar]
  24. Si K.J. Chen Y. Shi Q. Cheng W. Nanoparticle superlattices: The roles of soft ligands. Adv. Sci. 2018 5 1 1700179 10.1002/advs.201700179 29375958
    [Google Scholar]
  25. Albarqi H.A. Wong L.H. Schumann C. Sabei F.Y. Korzun T. Li X. Hansen M.N. Dhagat P. Moses A.S. Taratula O. Taratula O. Biocompatible nanoclusters with high heating efficiency for systemically delivered magnetic hyperthermia. ACS Nano 2019 13 6 6383 6395 10.1021/acsnano.8b06542 31082199
    [Google Scholar]
  26. Tang S. Fu C. Tan L. Liu T. Mao J. Ren X. Su H. Long D. Chai Q. Huang Z. Chen X. Wang J. Ren J. Meng X. Imaging-guided synergetic therapy of orthotopic transplantation tumor by superselectively arterial administration of microwave-induced microcapsules. Biomaterials 2017 133 144 153 10.1016/j.biomaterials.2017.04.027 28437625
    [Google Scholar]
  27. Wang J. Zhang Y. Jin N. Mao C. Yang M. Protein-induced gold nanoparticle assembly for improving the photothermal effect in cancer therapy. ACS Appl. Mater. Interfaces 2019 11 12 11136 11143 10.1021/acsami.8b21488 30869510
    [Google Scholar]
  28. Wang D. Guan J. Hu J. Bourgeois M.R. Odom T.W. Manipulating light–matter interactions in plasmonic nanoparticle lattices. Acc. Chem. Res. 2019 52 11 2997 3007 10.1021/acs.accounts.9b00345 31596570
    [Google Scholar]
  29. Ju H. Cui Y. Chen Z. Fu Q. Sun M. Zhou Y. Effects of combined delivery of extremely low frequency electromagnetic field and magnetic Fe3O4 nanoparticles on hepatic cell lines. Am. J. Transl. Res. 2016 8 4 1838 1847 27186307
    [Google Scholar]
  30. Neves A.R. Queiroz J.F. Costa Lima S.A. Figueiredo F. Fernandes R. Reis S. Cellular uptake and transcytosis of lipid-based nanoparticles across the intestinal barrier: Relevance for oral drug delivery. J. Colloid Interface Sci. 2016 463 258 265 10.1016/j.jcis.2015.10.057 26550783
    [Google Scholar]
  31. Chenthamara D. Subramaniam S. Ramakrishnan S.G. Krishnaswamy S. Essa M.M. Lin F.H. Qoronfleh M.W. Therapeutic efficacy of nanoparticles and routes of administration. Biomater. Res. 2019 23 1 20 10.1186/s40824‑019‑0166‑x 31832232
    [Google Scholar]
  32. Melchor-Martínez E.M. Torres Castillo N.E. Macias-Garbett R. Lucero-Saucedo S.L. Parra-Saldívar R. Sosa-Hernández J.E. Biotechnology, modern world applications for nano-bio materials: Tissue engineering and COVID-19. Front. Bioeng. Biotechnol. 2021 9 597958 10.3389/fbioe.2021.597958 34055754
    [Google Scholar]
  33. Nguyen T.X. Huang L. Liu L. Elamin Abdalla A.M. Gauthier M. Yang G. Chitosan-coated nano-liposomes for the oral delivery of berberine hydrochloride. J. Mater. Chem. B Mater. Biol. Med. 2014 2 41 7149 7159 10.1039/C4TB00876F 32261793
    [Google Scholar]
  34. Nabi B. Rehman S. Baboota S. Ali J. Insights on oral drug delivery of lipid nanocarriers: A win-win solution for augmenting bioavailability of antiretroviral drugs. AAPS PharmSciTech 2019 20 2 60 10.1208/s12249‑018‑1284‑9 30623263
    [Google Scholar]
  35. Xu Y. Shrestha N. Préat V. Beloqui A. Overcoming the intestinal barrier: A look into targeting approaches for improved oral drug delivery systems. J. Control. Release 2020 322 486 508 10.1016/j.jconrel.2020.04.006 32276004
    [Google Scholar]
  36. Nagendran I. Formulation and evaluation of controlled release floating matrix tablets of amivudine and stavudine. Asian J. Pharm. 2012 6 4 259
    [Google Scholar]
  37. Zhang M. Merlin D. Nanoparticle-based oral drug delivery systems targeting the colon for treatment of ulcerative colitis. Inflamm. Bowel Dis. 2018 24 7 1401 1415 10.1093/ibd/izy123 29788186
    [Google Scholar]
  38. Shahdadi Sardo H. Saremnejad F. Bagheri S. Akhgari A. Afrasiabi Garekani H. Sadeghi F. A review on 5-aminosalicylic acid colon-targeted oral drug delivery systems. Int. J. Pharm. 2019 558 367 379 10.1016/j.ijpharm.2019.01.022 30664993
    [Google Scholar]
  39. Colby A.H. Oberlies N.H. Pearce C.J. Herrera V.L.M. Colson Y.L. Grinstaff M.W. Nanoparticle drug‐delivery systems for peritoneal cancers: A case study of the design, characterization and development of the expansile nanoparticle. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2017 9 3 e1451 10.1002/wnan.1451 28185434
    [Google Scholar]
  40. Reymond M. Königsrainer, Optimizing intraperitoneal drug delivery: pressurized intraperitoneal aerosol chemotherapy A. In: Drug Delivery Trends. Elsevier 2020 197 214 10.1016/B978‑0‑12‑817870‑6.00010‑9
    [Google Scholar]
  41. Vickers N.J. Animal communication: When i’m calling you, will you answer too? Curr. Biol. 2017 27 14 R713 R715 10.1016/j.cub.2017.05.064 28743020
    [Google Scholar]
  42. Alyami M. Hübner M. Grass F. Bakrin N. Villeneuve L. Laplace N. Passot G. Glehen O. Kepenekian V. Pressurised intraperitoneal aerosol chemotherapy: rationale, evidence, and potential indications. Lancet Oncol. 2019 20 7 e368 e377 10.1016/S1470‑2045(19)30318‑3 31267971
    [Google Scholar]
  43. Carlier C. Mathys A. De Jaeghere E. Steuperaert M. De Wever O. Ceelen W. Tumour tissue transport after intraperitoneal anticancer drug delivery. Int. J. Hyperthermia 2017 33 5 534 542 10.1080/02656736.2017.1312563 28540828
    [Google Scholar]
  44. Van de Sande L. Cosyns S. Willaert W. Ceelen W. Albumin-based cancer therapeutics for intraperitoneal drug delivery: A review. Drug Deliv. 2020 27 1 40 53 10.1080/10717544.2019.1704945 31858848
    [Google Scholar]
  45. Yang S. Cai C. Wang H. Ma X. Shao A. Sheng J. Yu C. Drug delivery strategy in hepatocellular carcinoma therapy. Cell Commun. Signal. 2022 20 1 26 10.1186/s12964‑021‑00796‑x 35248060
    [Google Scholar]
  46. Kamble P. Sadarani B. Majumdar A. Bhullar S. Nanofiber based drug delivery systems for skin: A promising therapeutic approach. J. Drug Deliv. Sci. Technol. 2017 41 124 133 10.1016/j.jddst.2017.07.003
    [Google Scholar]
  47. Monteiro-Riviere N.A. Riviere J.E. Interaction of nanomaterials with skin: Aspects of absorption and biodistribution Nanotoxicology 2009 3 3 188 193 10.1080/17435390902906803
    [Google Scholar]
  48. Zhou X. Hao Y. Yuan L. Pradhan S. Shrestha K. Pradhan O. Liu H. Li W. Nano-formulations for transdermal drug delivery: A review. Chin. Chem. Lett. 2018 29 12 1713 1724 10.1016/j.cclet.2018.10.037
    [Google Scholar]
  49. Patel V. Sharma O.P. Mehta T. Nanocrystal: A novel approach to overcome skin barriers for improved topical drug delivery. Expert Opin. Drug Deliv. 2018 15 4 351 368 10.1080/17425247.2018.1444025 29465253
    [Google Scholar]
  50. Sala M. Diab R. Elaissari A. Fessi H. Lipid nanocarriers as skin drug delivery systems: Properties, mechanisms of skin interactions and medical applications. Int. J. Pharm. 2018 535 1-2 1 17 10.1016/j.ijpharm.2017.10.046 29111097
    [Google Scholar]
  51. Carter P. Narasimhan B. Wang Q. Biocompatible nanoparticles and vesicular systems in transdermal drug delivery for various skin diseases. Int. J. Pharm. 2019 555 49 62 10.1016/j.ijpharm.2018.11.032 30448309
    [Google Scholar]
  52. Rabiei M. Kashanian S. Samavati S.S. Jamasb S. McInnes S.J.P. Nanomaterial and advanced technologies in transdermal drug delivery. J. Drug Target. 2020 28 4 356 367 10.1080/1061186X.2019.1693579 31851847
    [Google Scholar]
  53. Paranjpe M. Müller-Goymann C. Nanoparticle-mediated pulmonary drug delivery: A review. Int. J. Mol. Sci. 2014 15 4 5852 5873 10.3390/ijms15045852 24717409
    [Google Scholar]
  54. Karra N. Swindle E.J. Morgan H. Drug delivery for traditional and emerging airway models. Organs Chip 2019 1 100002 10.1016/j.ooc.2020.100002
    [Google Scholar]
  55. Sankhe K. Khan T. Bhavsar C. Momin M. Omri A. Selective drug deposition in lungs through pulmonary drug delivery system for effective management of drug-resistant TB. Expert Opin. Drug Deliv. 2019 16 5 525 538 10.1080/17425247.2019.1609937 31007100
    [Google Scholar]
  56. Thakur A.K. Chellappan D.K. Dua K. Mehta M. Satija S. Singh I. Patented therapeutic drug delivery strategies for targeting pulmonary diseases. Expert Opin. Ther. Pat. 2020 30 5 375 387 10.1080/13543776.2020.1741547 32178542
    [Google Scholar]
  57. Gökbulak F. Effect of American bison (Bison bison L.) on the recovery and germinability of seeds of range forage species. Grass Forage Sci. 2002 57 4 395 400 10.1046/j.1365‑2494.2002.00330.x
    [Google Scholar]
  58. Chellappan D.K. Yee L.W. Xuan K.Y. Kunalan K. Rou L.C. Jean L.S. Ying L.Y. Wie L.X. Chellian J. Mehta M. Satija S. Singh S.K. Gulati M. Dureja H. Da Silva M.W. Tambuwala M.M. Gupta G. Paudel K.R. Wadhwa R. Hansbro P.M. Dua K. Targeting neutrophils using novel drug delivery systems in chronic respiratory diseases. Drug Dev. Res. 2020 81 4 419 436 10.1002/ddr.21648 32048757
    [Google Scholar]
  59. Csóka I. Karimi K. Mukhtar M. Ambrus R. Pulmonary drug delivery systems of antibiotics for the treatment of respiratory tract infections. Acta Pharm. Hung. 2019 89 2 43 62 10.33892/aph.2019.89.43‑62
    [Google Scholar]
  60. Mehta M. Deeksha; Sharma, N.; Vyas, M.; Khurana, N.; Maurya, P.K.; Singh, H.; Andreoli de Jesus, T.P.; Dureja, H.; Chellappan, D.K.; Gupta, G.; Wadhwa, R.; Collet, T.; Hansbro, P.M.; Dua, K.; Satija, S. Interactions with the macrophages: An emerging targeted approach using novel drug delivery systems in respiratory diseases. Chem. Biol. Interact. 2019 304 10 19 10.1016/j.cbi.2019.02.021 30849336
    [Google Scholar]
  61. Ho D.K. Nichols B.L.B. Edgar K.J. Murgia X. Loretz B. Lehr C.M. Challenges and strategies in drug delivery systems for treatment of pulmonary infections. Eur. J. Pharm. Biopharm. 2019 144 110 124 10.1016/j.ejpb.2019.09.002 31493510
    [Google Scholar]
  62. Kim C.G. Kye Y.C. Yun C.H. The role of nanovaccine in cross-presentation of antigen-presenting cells for the activation of CD8+ T cell responses. Pharmaceutics 2019 11 11 612 10.3390/pharmaceutics11110612 31731667
    [Google Scholar]
  63. Xu J. Lv J. Zhuang Q. Yang Z. Cao Z. Xu L. Pei P. Wang C. Wu H. Dong Z. Chao Y. Wang C. Yang K. Peng R. Cheng Y. Liu Z. A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy. Nat. Nanotechnol. 2020 15 12 1043 1052 10.1038/s41565‑020‑00781‑4 33139933
    [Google Scholar]
  64. Qiao Y. Wan J. Zhou L. Ma W. Yang Y. Luo W. Yu Z. Wang H. Stimuli‐responsive nanotherapeutics for precision drug delivery and cancer therapy. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2019 11 1 e1527 10.1002/wnan.1527 29726115
    [Google Scholar]
  65. Yin W. Li Y. Gu Y. Luo M. Nanoengineered targeting strategy for cancer immunotherapy. Acta Pharmacol. Sin. 2020 41 7 902 910 10.1038/s41401‑020‑0417‑3 32398683
    [Google Scholar]
  66. Thi T.T.H. Suys E.J.A. Lee J.S. Nguyen D.H. Park K.D. Truong N.P. Lipid-based nanoparticles in the clinic and clinical trials: From cancer nanomedicine to COVID-19 vaccines. Vaccines 2021 9 4 359 10.3390/vaccines9040359 33918072
    [Google Scholar]
  67. Kyriakidis N.C. López-Cortés A. González E.V. Grimaldos A.B. Prado E.O. SARS-CoV-2 vaccines strategies: A comprehensive review of phase 3 candidates. npj. Vaccines 2021 6 1 1 17 35062662
    [Google Scholar]
  68. Han L. Peng K. Qiu L.Y. Li M. Ruan J.H. He L.L. Yuan Z.X. Hitchhiking on controlled-release drug delivery systems: Opportunities and challenges for cancer vaccines. Front. Pharmacol. 2021 12 679602 10.3389/fphar.2021.679602 34040536
    [Google Scholar]
  69. Kon E. Elia U. Peer D. Principles for designing an optimal mRNA lipid nanoparticle vaccine. Curr. Opin. Biotechnol. 2022 73 329 336 10.1016/j.copbio.2021.09.016 34715546
    [Google Scholar]
  70. Noor R. Developmental status of the potential vaccines for the mitigation of the COVID-19 pandemic and a focus on the effectiveness of the Pfizer-BioNTech and moderna mRNA vaccines. Curr. Clin. Microbiol. Rep. 2021 8 3 178 185 10.1007/s40588‑021‑00162‑y 33686365
    [Google Scholar]
  71. Vu MN. Rajasekhar P. Poole DP. Khor SY. Truong NP. Nowell CJ. Quinn JF. Whittaker M. Veldhuis NA. Davis TP. Rapid assessment of nanoparticle extravasation in a microfluidic tumor model. Appl. Nano Mater. 2019 2 4 1844 1856
    [Google Scholar]
  72. Lohmann V. Rolland M. Truong N.P. Anastasaki A. Controlling size, shape, and charge of nanoparticles via low-energy miniemulsion and heterogeneous RAFT polymerization. Eur. Polym. J. 2022 176 111417 10.1016/j.eurpolymj.2022.111417
    [Google Scholar]
  73. Vu M.N. Kelly H.G. Wheatley A.K. Peng S. Pilkington E.H. Veldhuis N.A. Davis T.P. Kent S.J. Truong N.P. Cellular interactions of liposomes and PISA nanoparticles during human blood flow in a microvascular network. Small 2020 16 33 2002861 10.1002/smll.202002861 32583981
    [Google Scholar]
  74. Jackson T.C. Obiakor N.M. Iheanyichukwu I.N. Ita O.O. Ucheokoro A.S. Biotechnology and nanotechnology drug delivery: A review. J. Pharm. Pharmacol. 2021 9 127 132
    [Google Scholar]
  75. Hoang Thi T.T. Pilkington E.H. Nguyen D.H. Lee J.S. Park K.D. Truong N.P. The importance of poly (ethylene glycol) alternatives for overcoming PEG immunogenicity in drug delivery and bioconjugation. Polymers 2020 12 2 298 10.3390/polym12020298 32024289
    [Google Scholar]
  76. Zukancic D. Suys E.J.A. Pilkington E.H. Algarni A. Al-Wassiti H. Truong N.P. The importance of poly (Ethylene glycol) and lipid structure in targeted gene delivery to lymph nodes by lipid nanoparticles. Pharmaceutics 2020 12 11 1068 10.3390/pharmaceutics12111068 33182382
    [Google Scholar]
  77. Preda A. van Vliet M. Krestin G.P. Brasch R.C. van Dijke C.F. Magnetic resonance macromolecular agents for monitoring tumor microvessels and angiogenesis inhibition. Invest. Radiol. 2006 41 3 325 331 10.1097/01.rli.0000186565.21375.88 16481916
    [Google Scholar]
  78. von Minckwitz G. Martin M. Wilson G. Alba E. Schmidt M. Biganzoli L. Awada A. Optimizing taxane use in MBC in the emerging era of targeted chemotherapy. Crit. Rev. Oncol. Hematol. 2013 85 3 315 331 10.1016/j.critrevonc.2012.09.009 23116625
    [Google Scholar]
  79. Tacar O. Sriamornsak P. Dass C.R. Doxorubicin: An update on anticancer molecular action, toxicity and novel drug delivery systems. J. Pharm. Pharmacol. 2013 65 2 157 170 10.1111/j.2042‑7158.2012.01567.x 23278683
    [Google Scholar]
  80. Gudkov S.V. Shafeev G.A. Glinushkin A.P. Shkirin A.V. Barmina E.V. Rakov I.I. Simakin A.V. Kislov A.V. Astashev M.E. Vodeneev V.A. Kalinitchenko V.P. Production and use of selenium nanoparticles as fertilizers. ACS Omega 2020 5 28 17767 17774 10.1021/acsomega.0c02448 32715263
    [Google Scholar]
  81. Maiyo F. Singh M. Selenium nanoparticles: Potential in cancer gene and drug delivery. Nanomedicine (Lond.) 2017 12 9 1075 1089 10.2217/nnm‑2017‑0024 28440710
    [Google Scholar]
  82. Xuan G. Zhang M. Chen Y. Huang S. Lee I. Design and characterization of a cancer-targeted drug co-delivery system composed of liposomes and selenium Nanoparticles. J. Nanosci. Nanotechnol. 2020 20 9 5295 5304 10.1166/jnn.2020.17882 32331095
    [Google Scholar]
  83. Xia Y. Tang G. Wang C. Zhong J. Chen Y. Hua L. Li Y. Liu H. Zhu B. Functionalized selenium nanoparticles for targeted siRNA delivery silence Derlin1 and promote antitumor efficacy against cervical cancer. Drug Deliv. 2020 27 1 15 25 10.1080/10717544.2019.1667452 31830840
    [Google Scholar]
  84. Shahverdi A.R. Shahverdi F. Faghfuri E. Reza khoshayand, M.; Mavandadnejad, F.; Yazdi, M.H.; Amini, M. Characterization of folic acid surface-coated selenium nanoparticles and corresponding in vitro and in vivo effects against breast cancer. Arch. Med. Res. 2018 49 1 10 17 10.1016/j.arcmed.2018.04.007 29699810
    [Google Scholar]
  85. Kumar G.S. Kulkarni A. Khurana A. Kaur J. Tikoo K. Selenium nanoparticles involve HSP-70 and SIRT1 in preventing the progression of type 1 diabetic nephropathy. Chem. Biol. Interact. 2014 223 125 133 10.1016/j.cbi.2014.09.017 25301743
    [Google Scholar]
  86. Wang H. Wei W. Zhang S.Y. Shen Y.X. Yue L. Wang N.P. Xu S.Y. Melatonin‐selenium nanoparticles inhibit oxidative stress and protect against hepatic injury induced by Bacillus Calmette–Guérin/lipopolysaccharide in mice. J. Pineal Res. 2005 39 2 156 163 10.1111/j.1600‑079X.2005.00231.x 16098093
    [Google Scholar]
  87. Khurana A. Tekula S. Saifi M.A. Venkatesh P. Godugu C. Therapeutic applications of selenium nanoparticles. Biomed. Pharmacother. 2019 111 802 812 10.1016/j.biopha.2018.12.146 30616079
    [Google Scholar]
  88. Jahangirian H. Kalantari K. Izadiyan Z. Rafiee-Moghaddam R. Shameli K. Webster T.J. A review of small molecules and drug delivery applications using gold and iron nanoparticles. Int. J. Nanomedicine 2019 14 1633 1657 10.2147/IJN.S184723 30880970
    [Google Scholar]
  89. Shi J. Votruba A.R. Farokhzad O.C. Langer R. Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett. 2010 10 9 3223 3230 10.1021/nl102184c 20726522
    [Google Scholar]
  90. Priyadarsini S. Mohanty S. Mukherjee S. Basu S. Mishra M. Graphene and graphene oxide as nanomaterials for medicine and biology application. J. Nanostructure Chem. 2018 8 2 123 137 10.1007/s40097‑018‑0265‑6
    [Google Scholar]
  91. Jäger M. Schubert S. Ochrimenko S. Fischer D. Schubert U.S. Branched and linear poly(ethylene imine)-based conjugates: Synthetic modification, characterization, and application. Chem. Soc. Rev. 2012 41 13 4755 4767 10.1039/c2cs35146c 22648524
    [Google Scholar]
  92. Gurunathan S. Woong Han J. Kim E. Kwon D.N. Park J.K. Kim J.H. Enhanced green fluorescent protein-mediated synthesis of biocompatible graphene. J. Nanobiotechnology 2014 12 1 41 10.1186/s12951‑014‑0041‑9 25273520
    [Google Scholar]
  93. Li N. Zhang Q. Gao S. Song Q. Huang R. Wang L. Liu L. Dai J. Tang M. Cheng G. Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells. Sci. Rep. 2013 3 1 1604 10.1038/srep01604 23549373
    [Google Scholar]
  94. Orlando G. Wood K.J. Stratta R.J. Yoo J.J. Atala A. Soker S. Regenerative medicine and organ transplantation: Past, present, and future. Transplantation 2011 91 12 1310 1317 10.1097/TP.0b013e318219ebb5 21505379
    [Google Scholar]
  95. Ramos T. Moroni L. Tissue engineering and regenerative medicine 2019: The role of biofabrication-a year in review. Tissue Eng. Part C Methods 2020 26 2 91 106 10.1089/ten.tec.2019.0344 31856696
    [Google Scholar]
  96. Han F. Wang J. Ding L. Hu Y. Li W. Yuan Z. Guo Q. Zhu C. Yu L. Wang H. Zhao Z. Jia L. Li J. Yu Y. Zhang W. Chu G. Chen S. Li B. biotechnology, Tissue engineering and regenerative medicine: Achievements, future, and sustainability in Asia. Front. Bioeng. Biotechnol. 2020 8 83 10.3389/fbioe.2020.00083 32266221
    [Google Scholar]
  97. Şeker Ş. Elçin A.E. Elçin Y.M. Current trends in the design and fabrication of PRP-based scaffolds for tissue engineering and regenerative medicine. Biomed. Mater. 2025 20 2 022001 10.1088/1748‑605X/ada83f 39787704
    [Google Scholar]
  98. Garkal A. Bangar P. Avachat A. Pandit A. Paryani M. Sami A. Patel J. Butani S. Mehta T. In Handbook of Biodegradable Polymers. Jenny Stanford Publishing 2025 449 524
    [Google Scholar]
  99. Vishwanath R. Biswas A. Modi U. Gupta S. Bhatia D. Solanki R. Programmable short peptides for modulating stem cell fate in tissue engineering and regenerative medicine. J. Mater. Chem. B Mater. Biol. Med. 2025 13 8 2573 2591 10.1039/D4TB02102A 39871657
    [Google Scholar]
  100. Jang J.H. Bengali Z. Houchin T.L. Shea L.D. Surface adsorption of DNA to tissue engineering scaffolds for efficient gene delivery. J. Biomed. Mater. Res. A 2006 77A 1 50 58 10.1002/jbm.a.30643 16353173
    [Google Scholar]
  101. Zhou M. Liu N.X. Shi S.R. Li Y. Zhang Q. Ma Q.Q. Tian T.R. Ma W.J. Cai X. Lin Y.F. Effect of tetrahedral DNA nanostructures on proliferation and osteo/odontogenic differentiation of dental pulp stem cells via activation of the notch signaling pathway. Nanomedicine 2018 14 4 1227 1236 10.1016/j.nano.2018.02.004 29458214
    [Google Scholar]
  102. Gonzalez-Fernandez T. Rathan S. Hobbs C. Pitacco P. Freeman F.E. Cunniffe G.M. Dunne N.J. McCarthy H.O. Nicolosi V. O’Brien F.J. Kelly D.J. Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues. J. Control. Release 2019 301 13 27 10.1016/j.jconrel.2019.03.006 30853527
    [Google Scholar]
  103. Walsh D.P. Raftery R.M. Castaño I.M. Murphy R. Cavanagh B. Heise A. O’Brien F.J. Cryan S.A. Transfection of autologous host cells in vivo using gene activated collagen scaffolds incorporating star-polypeptides. J. Control. Release 2019 304 191 203 10.1016/j.jconrel.2019.05.009 31075346
    [Google Scholar]
  104. Zhu J. Zhang M. Gao Y. Qin X. Zhang T. Cui W. Mao C. Xiao D. Lin Y. Tetrahedral framework nucleic acids promote scarless healing of cutaneous wounds via the AKT-signaling pathway. Signal Transduct. Target. Ther. 2020 5 1 120 10.1038/s41392‑020‑0173‑3 32678073
    [Google Scholar]
  105. Li W. Wu D. Tan J. Liu Z. Lu L. Zhou C. A gene-activating skin substitute comprising PLLA/POSS nanofibers and plasmid DNA encoding ANG and bFGF promotes in vivo revascularization and epidermalization. J. Mater. Chem. B Mater. Biol. Med. 2018 6 43 6977 6992 10.1039/C8TB02006J 32254581
    [Google Scholar]
  106. Duman N. Duman R. Tosun M. Akıcı M. Göksel E. Gökçe B. Alagöz O. Topical folinic acid enhances wound healing in rat model. Adv. Med. Sci. 2018 63 2 347 352 10.1016/j.advms.2018.04.011 30092503
    [Google Scholar]
  107. Eke G. Mangir N. Hasirci N. MacNeil S. Hasirci V. Development of a UV crosslinked biodegradable hydrogel containing adipose derived stem cells to promote vascularization for skin wounds and tissue engineering. Biomaterials 2017 129 188 198 10.1016/j.biomaterials.2017.03.021 28343005
    [Google Scholar]
  108. Milan P.B. Lotfibakhshaiesh N. Joghataie M.T. Ai J. Pazouki A. Kaplan D.L. Kargozar S. Amini N. Hamblin M.R. Mozafari M. Samadikuchaksaraei A. Accelerated wound healing in a diabetic rat model using decellularized dermal matrix and human umbilical cord perivascular cells. Acta Biomater. 2016 45 234 246 10.1016/j.actbio.2016.08.053 27591919
    [Google Scholar]
  109. Bhowmick S. Scharnweber D. Koul V. Co-cultivation of keratinocyte-human mesenchymal stem cell (hMSC) on sericin loaded electrospun nanofibrous composite scaffold (cationic gelatin/hyaluronan/chondroitin sulfate) stimulates epithelial differentiation in hMSCs: In vitro study. Biomaterials 2016 88 83 96 10.1016/j.biomaterials.2016.02.034 26946262
    [Google Scholar]
  110. Keil T.W.M. Baldassi D. Merkel O.M. T‐cell targeted pulmonary siRNA delivery for the treatment of asthma. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2020 12 5 e1634 10.1002/wnan.1634 32267622
    [Google Scholar]
  111. Liang H. Yan Y. Wu J. Ge X. Wei L. Liu L. Chen Y. Topical nanoparticles interfering with the DNA-LL37 complex to alleviate psoriatic inflammation in mice and monkeys. Sci. Adv. 2020 6 31 eabb5274 10.1126/sciadv.abb5274 32923608
    [Google Scholar]
  112. Mao C. Pan W. Shao X. Ma W. Zhang Y. Zhan Y. Gao Y. Lin Y. The clearance effect of tetrahedral DNA nanostructures on senescent human dermal fibroblasts. ACS Appl. Mater. Interfaces 2019 11 2 1942 1950 10.1021/acsami.8b20530 30562007
    [Google Scholar]
  113. Shao X. Ma W. Xie X. Li Q. Lin S. Zhang T. Lin Y. Neuroprotective effect of tetrahedral DNA nanostructures in a cell model of Alzheimer’s disease. ACS Appl. Mater. Interfaces 2018 10 28 23682 23692 10.1021/acsami.8b07827 29927573
    [Google Scholar]
  114. Song H.H.G. Rumma R.T. Ozaki C.K. Edelman E.R. Chen C.S. Vascular tissue engineering: Progress, challenges, and clinical promise. Cell Stem Cell 2018 22 3 340 354 10.1016/j.stem.2018.02.009 29499152
    [Google Scholar]
  115. Tarassoli S.P. Jessop Z.M. Al-Sabah A. Gao N. Whitaker S. Doak S. Whitaker I.S. Skin tissue engineering using 3D bioprinting: An evolving research field. J. Plast. Reconstr. Aesthet. Surg. 2018 71 5 615 623 10.1016/j.bjps.2017.12.006 29306639
    [Google Scholar]
  116. Yu J.R. Navarro J. Coburn J.C. Mahadik B. Molnar J. Holmes J.H. Nam A.J. Fisher J.P. Current and future perspectives on skin tissue engineering: key features of biomedical research, translational assessment, and clinical application. Adv. Healthc. Mater. 2019 8 5 1801471 10.1002/adhm.201801471 30707508
    [Google Scholar]
  117. Miranda C.M.F.C. Leonel L.C.P.C. Cañada R.R. Maria D.A. Miglino M.A. Del Sol M. Lobo S. Effects of chemical and physical methods on decellularization of murine skeletal muscles. An Acad. Bras Cienc 2021 93 2 e20190942 10.1590/0001‑3765202120190942 34190843
    [Google Scholar]
  118. Hassanzadeh P. Atyabi F. Dinarvand R. Tissue engineering: Still facing a long way ahead. J. Control. Release 2018 279 181 197 10.1016/j.jconrel.2018.04.024 29655988
    [Google Scholar]
  119. Dufrane D. Impact of age on human adipose stem cells for bone tissue engineering. Cell Transplant. 2017 26 9 1496 1504 10.1177/0963689717721203 29113460
    [Google Scholar]
  120. Ho-Shui-Ling A. Bolander J. Rustom L.E. Johnson A.W. Luyten F.P. Picart C. Bone regeneration strategies: Engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives. Biomaterials 2018 180 143 162 10.1016/j.biomaterials.2018.07.017 30036727
    [Google Scholar]
  121. Kwee B.J. Mooney D.J. Biomaterials for skeletal muscle tissue engineering. Curr. Opin. Biotechnol. 2017 47 16 22 10.1016/j.copbio.2017.05.003 28575733
    [Google Scholar]
  122. Shih Y.V. Varghese S. Tissue engineered bone mimetics to study bone disorders ex vivo: Role of bioinspired materials. Biomaterials 2019 198 107 121 10.1016/j.biomaterials.2018.06.005 29903640
    [Google Scholar]
  123. Saldin L.T. Cramer M.C. Velankar S.S. White L.J. Badylak S.F. Extracellular matrix hydrogels from decellularized tissues: Structure and function. Acta Biomater. 2017 49 1 15 10.1016/j.actbio.2016.11.068 27915024
    [Google Scholar]
  124. Takebe T. Zhang B. Radisic M. Synergistic engineering: Organoids meet organs-on-a-chip. Cell Stem Cell 2017 21 3 297 300 10.1016/j.stem.2017.08.016 28886364
    [Google Scholar]
  125. Wubneh A. Tsekoura E.K. Ayranci C. Uludağ H. Current state of fabrication technologies and materials for bone tissue engineering. Acta Biomater. 2018 80 1 30 10.1016/j.actbio.2018.09.031 30248515
    [Google Scholar]
  126. Atasoy-Zeybek A. Kose G.T. Gene therapy strategies in bone tissue engineering and current clinical applications. Adv. Exp. Med. Biol. 2018 1119 85 101 10.1007/5584_2018_253 30051322
    [Google Scholar]
  127. Han F. Meng Q. Xie E. Li K. Hu J. Chen Q. Li J. Han F. Engineered biomimetic micro/nano-materials for tissue regeneration. Front. Bioeng. Biotechnol. 2023 11 1205792 10.3389/fbioe.2023.1205792 37469449
    [Google Scholar]
  128. Farjaminejad S. Hasani M. Farjaminejad R. Foroozandeh A. Abdouss M. Hasanzadeh M.J.C.P.T. Applications, The critical role of nano-hydroxyapatites as an advanced scaffold in drug delivery towards efficient bone regeneration: Recent progress and challenges. Carbohydr Polym. Technol Appl 2025 100692
    [Google Scholar]
  129. Ullah S. Zainol I. Fabrication and applications of biofunctional collagen biomaterials in tissue engineering. Int. J. Biol. Macromol. 2025 298 139952 10.1016/j.ijbiomac.2025.139952 39824416
    [Google Scholar]
  130. Tian H. Yao J. Ba Q. Meng Y. Cui Y. Quan L. Gong W. Wang Y. Yang Y. Yang M. Gao C. Cerebral biomimetic nano-drug delivery systems: A frontier strategy for immunotherapy. J. Control. Release 2024 376 1039 1067 10.1016/j.jconrel.2024.10.058 39505218
    [Google Scholar]
  131. Vijayakumar S. González-Sánchez Z.I. Divya M. Amanullah M. Durán-Lara E.F. Li M. Efficacy of chondroitin sulfate as an emerging biomaterial for cancer-targeted drug delivery: A short review. Int. J. Biol. Macromol. 2024 283 Pt 2 137704 10.1016/j.ijbiomac.2024.137704 39549800
    [Google Scholar]
  132. Ling D. Dynamic nanoassembly-based drug delivery systems on the horizon. J. Control. Release 2021 339 547 552 10.1016/j.jconrel.2021.08.045 34478749
    [Google Scholar]
  133. Faingold A. Cohen S.R. Reznikov N. Wagner H.D. Osteonal lamellae elementary units: Lamellar microstructure, curvature and mechanical properties. Acta Biomater. 2013 9 4 5956 5962 10.1016/j.actbio.2012.11.032 23220032
    [Google Scholar]
  134. Raftery R.M. Walsh D.P. Castaño I.M. Heise A. Duffy G.P. Cryan S.A. O’Brien F.J. Delivering nucleic‐acid based nanomedicines on biomaterial scaffolds for orthopedic tissue repair: challenges, progress and future perspectives. Adv. Mater. 2016 28 27 5447 5469 10.1002/adma.201505088 26840618
    [Google Scholar]
  135. Betz V.M. Kochanek S. Rammelt S. Müller P.E. Betz O.B. Messmer C. Recent advances in gene‐enhanced bone tissue engineering. J. Gene Med. 2018 20 6 e3018 10.1002/jgm.3018 29601661
    [Google Scholar]
  136. Balmayor E.R. Evans C.H. RNA therapeutics for tissue engineering. Tissue Eng. Part A 2019 25 1-2 9 11 10.1089/ten.tea.2018.0315 30426843
    [Google Scholar]
  137. Khorsand B. Nicholson N. Do A.V. Femino J.E. Martin J.A. Petersen E. Guetschow B. Fredericks D.C. Salem A.K. Regeneration of bone using nanoplex delivery of FGF-2 and BMP-2 genes in diaphyseal long bone radial defects in a diabetic rabbit model. J. Control. Release 2017 248 53 59 10.1016/j.jconrel.2017.01.008 28069556
    [Google Scholar]
  138. Schlickewei C. Klatte T.O. Wildermuth Y. Laaff G. Rueger J.M. Ruesing J. Chernousova S. Lehmann W. Epple M. A bioactive nano-calcium phosphate paste for in-situ transfection of BMP-7 and VEGF-A in a rabbit critical-size bone defect: Results of an in vivo study. J. Mater. Sci. Mater. Med. 2019 30 2 15 10.1007/s10856‑019‑6217‑y 30671652
    [Google Scholar]
  139. Takanche J.S. Kim J.-E. Kim J.-S. Lee M.-H. Jeon J.-G. Park I.-S. Yi H.-K. Chitosan-gold nanoparticles mediated gene delivery of c-myb facilitates osseointegration of dental implants in ovariectomized rat. Artif. Cells Nanomed Biotechnol 2018 46 sup3 S807 S817 10.1080/21691401.2018.1513940
    [Google Scholar]
  140. Huang M. Zhang X. Li J. Li Y. Wang Q. Teng W. Comparison of osteogenic differentiation induced by siNoggin and pBMP-2 delivered by lipopolysaccharide-amine nanopolymersomes and underlying molecular mechanisms. Int. J. Nanomedicine 2019 14 4229 4245 10.2147/IJN.S203540 31239677
    [Google Scholar]
  141. Li Y. Liu C. Nanomaterial-based bone regeneration. Nanoscale 2017 9 15 4862 4874 10.1039/C7NR00835J 28358401
    [Google Scholar]
  142. Wang S.J. Jiang D. Zhang Z.Z. Chen Y.R. Yang Z.D. Zhang J.Y. Shi J. Wang X. Yu J.K. Biomimetic nanosilica–collagen scaffolds for in situ bone regeneration: Toward a cell‐free, one‐step surgery. Adv. Mater. 2019 31 49 1904341 10.1002/adma.201904341 31621958
    [Google Scholar]
  143. Mohammadi M. Mousavi Shaegh S.A. Alibolandi M. Ebrahimzadeh M.H. Tamayol A. Jaafari M.R. Ramezani M. Micro and nanotechnologies for bone regeneration: Recent advances and emerging designs. J. Control. Release 2018 274 35 55 10.1016/j.jconrel.2018.01.032 29410062
    [Google Scholar]
  144. Lv L. Liu Y. Zhang P. Zhang X. Liu J. Chen T. Su P. Li H. Zhou Y. The nanoscale geometry of TiO2 nanotubes influences the osteogenic differentiation of human adipose-derived stem cells by modulating H3K4 trimethylation. Biomaterials 2015 39 193 205 10.1016/j.biomaterials.2014.11.002 25468371
    [Google Scholar]
  145. D’Mello S. Atluri K. Geary S.M. Hong L. Elangovan S. Salem A.K. Bone regeneration using gene-activated matrices. AAPS J. 2017 19 1 43 53 10.1208/s12248‑016‑9982‑2 27655418
    [Google Scholar]
  146. Higashi T. Khalil I.A. Maiti K.K. Lee W.S. Akita H. Harashima H. Chung S.K. Novel lipidated sorbitol-based molecular transporters for non-viral gene delivery. J. Control. Release 2009 136 2 140 147 10.1016/j.jconrel.2009.01.024 19331845
    [Google Scholar]
  147. Nie H. Wang C.H. Fabrication and characterization of PLGA/HAp composite scaffolds for delivery of BMP-2 plasmid DNA. J. Control. Release 2007 120 1-2 111 121 10.1016/j.jconrel.2007.03.018 17512077
    [Google Scholar]
  148. Saleem M. Syed Khaja AS. Moursi S. Altamimi TA. Alharbi MS. Usman K. Khan MS. Alaskar A. Alam MJ. Narrative review on nanoparticles based on current evidence: Therapeutic agents for diabetic foot infection. Naunyn Schmiedebergs Arch. Pharmacol. 2024 397 9 6275 6297
    [Google Scholar]
  149. Qiao C. Zhang K. Jin H. Miao L. Shi C. Liu X. Yuan A. Liu J. Li D. Zheng C. Zhang G. Li X. Yang B. Sun H. Using poly(lactic-co-glycolic acid) microspheres to encapsulate plasmid of bone morphogenetic protein 2/polyethylenimine nanoparticles to promote bone formation in vitro and in vivo. Int. J. Nanomedicine 2013 8 2985 2995 23990717
    [Google Scholar]
  150. Qiao C. Zhang K. Sun B. Liu J. Song J. Hu Y. Yang S. Sun H. Yang B. Sustained release poly (lactic-co-glycolic acid) microspheres of bone morphogenetic protein 2 plasmid/calcium phosphate to promote in vitro bone formation and in vivo ectopic osteogenesis. Am. J. Transl. Res. 2015 7 12 2561 2572 26885257
    [Google Scholar]
  151. Hadjicharalambous C. Kozlova D. Sokolova V. Epple M. Chatzinikolaidou M. Calcium phosphate nanoparticles carrying BMP‐7 plasmid DNA induce an osteogenic response in MC3T3‐E1 pre‐osteoblasts. J. Biomed. Mater. Res. A 2015 103 12 3834 3842 10.1002/jbm.a.35527 26097146
    [Google Scholar]
  152. Bhattarai G. Lee Y.H. Lee M.H. Yi H.K. Gene delivery of c-myb increases bone formation surrounding oral implants. J. Dent. Res. 2013 92 9 840 845 10.1177/0022034513497753 23838059
    [Google Scholar]
  153. Li H. Ji Q. Chen X. Sun Y. Xu Q. Deng P. Hu F. Yang J. Accelerated bony defect healing based on chitosan thermosensitive hydrogel scaffolds embedded with chitosan nanoparticles for the delivery of BMP2 plasmid DNA. J. Biomed. Mater. Res. A 2017 105 1 265 273 10.1002/jbm.a.35900 27636714
    [Google Scholar]
  154. Supper S. Anton N. Seidel N. Riemenschnitter M. Curdy C. Vandamme T. Thermosensitive chitosan/glycerophosphate-based hydrogel and its derivatives in pharmaceutical and biomedical applications. Expert Opin. Drug Deliv. 2014 11 2 249 267 10.1517/17425247.2014.867326 24304097
    [Google Scholar]
  155. Carballo-Pedrares N. Fuentes-Boquete I. Díaz-Prado S. Rey-Rico A. Hydrogel-based localized nonviral gene delivery in regenerative medicine approaches-An overview. Pharmaceutics 2020 12 8 752 10.3390/pharmaceutics12080752 32785171
    [Google Scholar]
  156. Lauritano D. Limongelli L. Moreo G. Favia G. Carinci F. Nanomaterials for periodontal tissue engineering: Chitosan-based scaffolds. A systematic review. Nanomaterials 2020 10 4 605 10.3390/nano10040605 32218206
    [Google Scholar]
  157. Wu S. Zhou Y. Yu Y. Zhou X. Du W. Wan M. Fan Y. Zhou X. Xu X. Zheng L. Evaluation of chitosan hydrogel for sustained delivery of VEGF for odontogenic differentiation of dental pulp stem cells. Stem Cells Int. 2019 1515040 10.1155/2019/1515040
    [Google Scholar]
  158. Walsh D.P. Murphy R.D. Panarella A. Raftery R.M. Cavanagh B. Simpson J.C. O’Brien F.J. Heise A. Cryan S.A. Bioinspired star-shaped poly (l-lysine) polypeptides: efficient polymeric nanocarriers for the delivery of DNA to mesenchymal stem cells. Mol. Pharm. 2018 15 5 1878 1891 10.1021/acs.molpharmaceut.8b00044 29590755
    [Google Scholar]
  159. Shinozaki Y. Toda M. Ohno J. Kawaguchi M. Kido H. Fukushima T. Evaluation of bone formation guided by DNA/protamine complex with FGF‐2 in an adult rat calvarial defect model. J. Biomed. Mater. Res. B Appl. Biomater. 2014 102 8 1669 1676 10.1002/jbm.b.33143 24664968
    [Google Scholar]
  160. Toda M. Ohno J. Shinozaki Y. Ozaki M. Fukushima T. Osteogenic potential for replacing cells in rat cranial defects implanted with a DNA/protamine complex paste. Bone 2014 67 237 245 10.1016/j.bone.2014.07.018 25051019
    [Google Scholar]
/content/journals/cdd/10.2174/0115672018378493251006062026
Loading
Nano Biomaterials in Drug Delivery and Tissue Engineering
Bentham Science Publishers ; https://doi.org/10.2174/0115672018378493251006062026
/content/journals/cdd/10.2174/0115672018378493251006062026
/content/journals/cdd/10.2174/0115672018378493251006062026
Loading

Data & Media loading...


  • Article Type:     Review Article
Keywords: tissue engineering ; nanoparticle ; regenerative medicine ; cancer therapy ; nano vaccines ; Nano biomaterials ; drug delivery

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test