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2000
Volume 7, Issue 4
  • ISSN: 1573-403X
  • E-ISSN: 1875-6557

Abstract

Anthracyclines, such as doxorubicin and idarubicin, remain an important class of chemotherapeutic agents. Unfortunately, their efficacy in treating cancer is limited by a cumulative dose-dependent cardiotoxicity, which can cause irreversible heart failure. In this review, we discuss the pathogenesis and incidence of anthracycline-induced cardiotoxicity as well as methods to detect, prevent and treat the condition.

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/content/journals/ccr/10.2174/157340311799960645
2011-11-01
2025-10-06

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  • Article Type:     Research Article
Keyword(s): ardiotoxicity; Cancer chemotherapy; doxorubicin; Fenton reaction; late cardiotoxicity; Left ventricular dysfunction; LVEF; oxidant stress; pediatric malignancies; ventricular dysfunction

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