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2000
Volume 3, Issue 1
  • ISSN: 2666-7312
  • E-ISSN: 2666-7339

Abstract

Aims

This study aimed to identify the potential release of the drug from the tablet dosage form using Carbopol-934 and Guar Gum polymers at different concentration ratios.

Objective

The objective of this study was to determine the cumulative percentage of ciprofloxacin hydrochloride released from different polymers.

Methods

We formulated ciprofloxacin hydrochloride sustained-release tablets with Carbopol-934 and Guar gum using the wet granulation method. For the formulation of sustained-release ciprofloxacin hydrochloride tablets, both polymers were mixed in varying ratios. The tablets were examined for pre-formulation studies, including the angle of repose, bulk density, compressibility index, and physiological properties, such as variations in weight, friability, and drug content. For post-formulation studies, such as the study, the release of the drugs was evaluated in a phosphate buffer solution (pH 7.4) for 8 h. However, the physiological properties of ciprofloxacin hydrochloride tablets were limited due to their liberality.

Results

The tablets containing guar gum (Batches B-I and B-II) showed better drug content than other polymer-based batches, such as Carbopol-934 (Batch A-I, A-II) and a mixture of both polymer Carbopol-934 and Guar gum (Batch C-I, C-II). Sustained drug release was observed in the guar gum polymer-based tablets (Batch B-II). It was observed that the dissolution profile of ciprofloxacin hydrochloride tablets formed using different polymers showed an increase in the polymer ratio, which can be related to the increase in drug release.

Conclusion

From this study, we can conclude that the ciprofloxacin hydrochloride drug release percentage was maximum when guar gum polymer was used in the tablet dosage form.

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2025-09-05

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/content/journals/cam/10.2174/0126667312330882241017040502
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Comparative Dissolution Study of Ciprofloxacin Hydrochloride-sustained Release Tablets by using Carbopol-934 and Guar Gum Polymers
Curr. Appl. Mat. 3, E26667312330882 (2024); https://doi.org/10.2174/0126667312330882241017040502
/content/journals/cam/10.2174/0126667312330882241017040502
/content/journals/cam/10.2174/0126667312330882241017040502
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  • Article Type:     Research Article
Keyword(s): carbopol-934; Ciprofloxacin hydrochloride; guar gum; polymers; sustained release tablet matrix

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