Skip to content
2000
Volume 19, Issue 1
  • ISSN: 1573-4099
  • E-ISSN: 1875-6697

Abstract

Background: A network pharmacology study on the biological action of Tripterygium wilfordii on myocardial fibrosis (MF). Methods: The effective components and potential targets of tripterygium wilfordii were screened from the TCMSP database to develop a combination target network. A protein-protein interaction network was constructed by analyzing the interaction between tripterygium wilfordii and MF; then, the Gene Ontology (GO) classification and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was performed. Furthermore, molecular docking was utilized to verify the network analysis results. Results: It was predicted that MF has 29 components contributing to its effectiveness and 87 potential targets. It is predicted that Tripterygium wilfordii has 29 active components and 87 potential targets for the treatment of MF. The principal active components of tripterygium wilfordii include kaempferol, β-sitosterol, triptolide, and Nobiletin. Signaling pathways: AGE-RAGE, PI3K-Akt, and MAPK may be involved in the mechanism of its action.7 Seven key targets (TNF, STAT3, AKT1, TP53, VEGFA, CASP3, STAT1) are possibly involved in treating MF by tripterygium wilfordii. Conclusion: This study shows the complex network relationship between multiple components, targets, and pathways of Tripterygium wilfordii in treating MF.

Loading

Article metrics loading...

/content/journals/cad/10.2174/1573409919666221028120329
2023-02-01
2024-12-11
Loading full text...

Full text loading...

/content/journals/cad/10.2174/1573409919666221028120329
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test