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image of Validation of the Mechanism of Action of Jiedu Shengji Oil in the Treatment of Radiation Dermatitis based on Network Pharmacology and In vivo Experiments

Abstract

Background

Radiation Dermatitis (RD) is a common complication of radiation therapy, with approximately 90% of patients experiencing moderate to severe radiation dermatitis injury after radiotherapy. Jiedu Shengji oil (JDSJY) is a commonly used herbal topical preparation in our hospital, with remarkable clinical efficacy in treating radiation dermatitis. However, the mechanism of JDSJY in treating RD is unclear.

Aims

The aim of the study is to explore JDSJY's mechanism of action in treating RD through methods, such as network pharmacology and experiments.

Methods

The active components and disease targets of JDSJY were screened and intersected network pharmacology for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. The pharmacodynamics of JDSJY was evaluated by establishing a rat model of RD.

Results

Network pharmacology showed that the pathway network of JDSJY action involved 64 targets and 6 pathways and might act by targeting key targets, such as C-reactive protein (CRP) and regulating the MAPK signalling pathway. In addition, experiments showed that JDSJY reduced skin inflammation and inhibited apoptosis, significantly ameliorated mitochondrial damage in keratinocytes, and reduced the levels of antioxidant-related indicators.

Conclusion

Comprehensive network pharmacology and experiments revealed that JDSJY's therapeutic efficacy in RD is mediated by ameliorating oxidative stress and maintaining mitochondrial homeostasis in keratinocytes.

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2025-05-16
2025-12-06

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/content/journals/cad/10.2174/0115734099370851250512074033
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Validation of the Mechanism of Action of Jiedu Shengji Oil in the Treatment of Radiation Dermatitis based on Network Pharmacology and In vivo Experiments
Bentham Science Publishers ; https://doi.org/10.2174/0115734099370851250512074033
/content/journals/cad/10.2174/0115734099370851250512074033
/content/journals/cad/10.2174/0115734099370851250512074033
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  • Article Type:     Research Article
Keywords: network pharmacology ; Jiedu Shengji Oil ; Radiation dermatitis ; in vivo experiments ; traditional Chinese medicine

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