Experimental and Bioinformatical Studies on Antimalarial Drug Sulfadiazine

Background: Several computational tools assist in predicting the chemical properties, toxicity, solubility, and binding affinity of the drugs. Objective: The study aims to experimentally analyze the efficiency of the antimalarial drug “sulfadiazine” in a higher dose in contrast to its conventional use. Methods: The antimalarial drug was screened, and its application was assessed on the host (mice). Results: The results showed that parasitemia of the infected control group was significantly higher than the others (P<0.0001) on days 3, 5, 7, and 9. The parasitemia of the IT+4 group was significantly lower than the parasitemia of the IT-4 group on the 15^th day. Conclusion: It was concluded that increased potency for the antimalarials is because they are nontoxic.