Phytochemical Screening, Antimalarial, Antioxidant, Anti-inflammatory, and Antimicrobial Potential of Ananas comosus Extract

Introduction: This study was undertaken to assess the antimicrobial, antioxidant, antiinflammatory and antimalarial potential of fruit extract of Ananas comosus Linn. Bromelain is the major protease enzyme present in the pineapple. Methods: Screening of compounds using fluorescence-based assay was performed for antimalarial activity by Trager and Jenson method. Ethanolic extract of ananas cosmosus showed good antimalarial activity (EC50 = 1.94 ug/ml) as compared to the standard drug primaquine (EC50 = 0.07 ug/ml). In the case of antibacterial activity, ethanolic extract of pineapple showed the good MIC value, i.e. S. aureus (MIC= 3.12 ug/ml), S. typhi (MIC = 3.12 ug/ml) as compared to the standard drug ofloxacin (MIC= 0.43 ug/ml). Results: In the case of antifungal activity extract showed the remarkable activity A. niger (MIC= 1.56 ug/ml) as compared to the standard drug fluconazole (MIC = 0.10 ug/ml). In the case of antioxidant activity, % inhibition was found i.e. 44.13 %, which is nearly equal to the standard drug 48 %. Conclusion: Ananas cosmosus showed excellent antioxidant potential.