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2000
Volume 26, Issue 2
  • ISSN: 1871-5206
  • E-ISSN: 1875-5992

Abstract

Introduction

Chemotherapy-induced gastrointestinal reactions are common in non-small cell lung cancer (NSCLC) patients undergoing carboplatin-based chemotherapy. Jianpi Yiwei granules (JPYW), a traditional Chinese medicine (TCM) formula, can alleviate these symptoms.

Materials and Methods

This multi-center, randomized, double-blind, placebo-controlled trial enrolled 136 NSCLC patients scheduled for carboplatin-based chemotherapy. Participants were randomly assigned to the treatment group (JPYW with standard antiemetic drugs) and the control group (placebo with standard antiemetic drugs). The complete control rate of nausea and vomiting was assessed using the Visual Analog Scale (VAS) and patient diaries. Control of anorexia, bloating, constipation, and quality of life was measured using the Functional Living Index-Emesis scale and the Brief Fatigue Inventory (BFI).

Results

The primary objective of this study was to assess the efficacy of JPYW in alleviating non-vomiting digestive symptoms, such as nausea and anorexia, in NSCLC patients receiving carboplatin-based chemotherapy. The secondary objective was to evaluate its effect on improving bloating, constipation, quality of life, and safety.

Discussion

Previous studies have shown that Chinese herbs, such as ginger, are effective in treating chemotherapy-induced nausea and vomiting (CINV). JPYW, a multi-component TCM formula, contains active compounds from and . JPYW exerts anti-inflammatory and prokinetic effects that can synergistically regulate gastrointestinal functions. Preliminary observations confirmed the safety of JPYW combined with standard chemotherapy.

Conclusion

The current findings contribute to the treatment of adverse reactions to tumor chemotherapy and are expected to improve the quality of life for chemotherapy patients.

China Clinical Trial Registration Center

(ChiCTR2400092390).

© 2026 Bentham Science Publishers
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References

  1. TangZ. WangL. WuG. QinL. TanY. FGD5 as a novel prognostic biomarker and its association with immune infiltrates in lung adenocarcinoma.Biocell202347112503251610.32604/biocell.2023.031565
     [Google Scholar]
  2. CaoH. XueY. WangF. LiG. ZhenY. GuoJ. Identification of prognostic molecular subtypes and model based on CD8+ T cells for lung adenocarcinoma.Biocell202448347349010.32604/biocell.2024.048946
     [Google Scholar]
  3. SiegelR.L. MillerK.D. WagleN.S. JemalA. Cancer statistics, 2023.CA Cancer J. Clin.2023731174810.3322/caac.21763 36633525
     [Google Scholar]
  4. QianX.J. WangJ.W. LiuJ.B. YuX. The mediating role of miR-451/ETV4/MMP13 signaling axis on epithelialmesenchymal transition in promoting non-small cell lung cancer progression.Curr. Mol. Pharmacol.202317e21072321898810.2174/1874467217666230721123554 37489792
     [Google Scholar]
  5. GuoH. HouY. WangC. DingJ. How to optimize the immune checkpoint blockade therapy for cancers?Oncologie202426334334810.1515/oncologie‑2024‑0037
     [Google Scholar]
  6. MeyerM.L. FitzgeraldB.G. Paz-AresL. CappuzzoF. JänneP.A. PetersS. HirschF.R. New promises and challenges in the treatment of advanced non-small-cell lung cancer.Lancet20244041045480382210.1016/S0140‑6736(24)01029‑8 39121882
     [Google Scholar]
  7. GuoS.B. HuL.S. HuangW.J. ZhouZ.Z. LuoH.Y. TianX.P. Comparative investigation of neoadjuvant immunotherapy versus adjuvant immunotherapy in perioperative patients with cancer: A global-scale, cross-sectional, and large-sample informatics study.Int. J. Surg.202411084660467110.1097/JS9.0000000000001479 38652128
     [Google Scholar]
  8. RielyG.J. WoodD.E. EttingerD.S. AisnerD.L. AkerleyW. BaumanJ.R. BharatA. BrunoD.S. ChangJ.Y. ChirieacL.R. DeCampM. DesaiA.P. DillingT.J. DowellJ. DurmG.A. GettingerS. GrotzT.E. GubensM.A. JulooriA. LacknerR.P. LanutiM. LinJ. LooB.W. LovlyC.M. MaldonadoF. MassarelliE. MorgenszternD. MullikinT.C. NgT. OwenD. OwenD.H. PatelS.P. PatilT. PolancoP.M. RiessJ. ShapiroT.A. SinghA.P. StevensonJ. TamA. TanvetyanonT. YanagawaJ. YangS.C. YauE. GregoryK.M. HangL. Non–small cell lung cancer, version 4.2024.J. Natl. Compr. Canc. Netw.202422424927410.6004/jnccn.2204.0023 38754467
     [Google Scholar]
  9. SundarR. NakayamaI. MarkarS.R. ShitaraK. van LaarhovenH.W.M. JanjigianY.Y. SmythE.C. Gastric cancer.Lancet2025405104942087210210.1016/S0140‑6736(25)00052‑2 40319897
     [Google Scholar]
  10. HeM. XuR. LiuM. ZhangY. YiF. WeiY. LiuQ. ZhangW. Use of dexamethasone and a 5-HT3 receptor antagonist with or without aprepitant to prevent chemotherapy-induced nausea and vomiting among patients with lung cancer who are treated with platinum-based chemotherapy: A systematic review and meta-analysis of randomized controlled trials.Ann. Palliat. Med.20211044308431910.21037/apm‑20‑2290 33894731
     [Google Scholar]
  11. BošnjakS.M. GrallaR.J. SchwartzbergL. Prevention of chemotherapy-induced nausea: The role of neurokinin-1 (NK1) receptor antagonists.Support. Care Cancer20172551661167110.1007/s00520‑017‑3585‑z
     [Google Scholar]
  12. Borroto-EscuelaD.O. AmbroginiP. ChruścickaB. LindskogM. Crespo-RamirezM. Hernández-MondragónJ.C. Perez de la MoraM. SchellekensH. FuxeK. The role of central serotonin neurons and 5-ht heteroreceptor complexes in the pathophysiology of depression: A historical perspective and future prospects.Int. J. Mol. Sci.2021224192710.3390/ijms22041927 33672070
     [Google Scholar]
  13. MolfinoA. de van der SchuerenM.A.E. Sánchez-LaraK. MilkeP. AmabileM.I. ImbimboG. Di LazzaroL. CavutoS. RonzaniG. SnegovoyA. GioulbasanisI. LavianoA. Cancer-associated anorexia: Validity and performance overtime of different appetite tools among patients at their first cancer diagnosis.Clin. Nutr.20214064037404210.1016/j.clnu.2021.02.016 33676774
     [Google Scholar]
  14. ChengY. WuZ. ShiL. ShenC. ZhangJ. HuH. LiW. CaiY. XieX. LingJ. ZhengQ. DengY. Aprepitant plus palonosetron versus dexamethasone plus palonosetron in preventing chemotherapy-induced nausea and vomiting in patients with moderate-emetogenic chemotherapy: A randomized, open-label, phase 3 trial. EClini.Medicine20224910148010.1016/j.eclinm.2022.101480 35747189
     [Google Scholar]
  15. XinY. SangY. JiX. TangM. ChenL. HaoY. LuJ. Explore the constituents and mechanism of traditional chinese medicine preparation zhachong shisan pills based on HPLC-QTOF-MS and network pharmacology.Curr. Pharm. Anal.202319971273410.2174/0115734129259758230924070432
     [Google Scholar]
  16. XiaoX. LiuY. HuangY. ZengW. LuoZ. Identification of the NF-κB inhibition peptides in asthma from Pheretima aspergillum decoction and formula granules using molecular docking and dynamics simulations.Curr. Pharm. Anal.202420320221110.2174/0115734129298587240322073956
     [Google Scholar]
  17. ZhaiX. HeQ. ChenM. YuL. TongC. ChenY. WangJ. FanX. XieH. LiangZ. SuiX. ZengL. WuQ. Pinellia ternata-containing traditional Chinese medicine combined with 5-HT3RAs for chemotherapy-induced nausea and vomiting: A PRISMA-compliant systematic review and meta-analysis of 22 RCTs.Phytomedicine202311515482310.1016/j.phymed.2023.154823 37099981
     [Google Scholar]
  18. ZhaoY.Z. DaiY.Z. NieK. Research progress on the antiemetic effect of traditional chinese medicine against chemotherapy-induced nausea and vomiting: A review.Front. Pharmacol.20221279078410.3389/fphar.2021.790784 35222008
     [Google Scholar]
  19. YanW. FengQ. LiY. LinY. YaoJ. JiaZ. LuL. LiuL. ZhouH. Integrated network pharmacology and DSS-induced colitis model to determine the anti-colitis effect of Rheum palmatum L. and Coptis chinensis Franch in granules.J. Ethnopharmacol.202330011567510.1016/j.jep.2022.115675 36075275
     [Google Scholar]
  20. LiuZ. ZhangJ. LiuJ. GuoL. ChenG. FangY. YangY. Combining network pharmacology, molecular docking and preliminary experiments to explore the mechanism of action of FZKA formula on non-small cell lung cancer.Protein Pept. Lett.202330121038104710.2174/0109298665268153231024111622 37962044
     [Google Scholar]
  21. ZhangX. SunQ.J. ZhaoL. ChenL. LiW. Traditional Chinese medicine in chronic rhinosinusitis: Mechanisms and postoperative recovery.Phytomedicine202514115665810.1016/j.phymed.2025.156658 40138776
     [Google Scholar]
  22. ChenP. WuH.Y. Network pharmacology- and molecular docking-based exploration of the molecular mechanism underlying Jianpi Yiwei Recipe treatment of gastric cancer.World J. Gastrointest. Oncol.20241672988299810.4251/wjgo.v16.i7.2988 39072163
     [Google Scholar]
  23. OhnishiS. WatariH. KannoM. OhbaY. TakeuchiS. MiyajiT. OyamadaS. NomuraE. KatoH. SugiyamaT. AsakaM. SakuragiN. YamaguchiT. UezonoY. IwaseS. Additive effect of rikkunshito, an herbal medicine, on chemotherapy-induced nausea, vomiting, and anorexia in uterine cervical or corpus cancer patients treated with cisplatin and paclitaxel: Results of a randomized phase II study (JORTC KMP-02).J. Gynecol. Oncol.2017285e4410.3802/jgo.2017.28.e44 28657216
     [Google Scholar]
  24. SchmollH.J. AaproM.S. Poli-BigelliS. KimH.K. ParkK. JordanK. von PawelJ. GiezekH. AhmedT. ChanC.Y. Comparison of an aprepitant regimen with a multiple-day ondansetron regimen, both with dexamethasone, for antiemetic efficacy in high-dose cisplatin treatment.Ann. Oncol.20061761000100610.1093/annonc/mdl019 16524979
     [Google Scholar]
  25. Poli-BigelliS. Rodrigues-PereiraJ. CaridesA.D. JulieM.G. EldridgeK. HippleA. EvansJ.K. HorganK.J. LawsonF. Addition of the neurokinin 1 receptor antagonist aprepitant to standard antiemetic therapy improves control of chemotherapy-induced nausea and vomiting.Cancer200397123090309810.1002/cncr.11433 12784346
     [Google Scholar]
  26. HayashiT. ShimokawaM. MatsuoK. IiharaH. KawadaK. NakanoT. EgawaT. Chemotherapy-induced nausea and vomiting (CINV) with carboplatin plus pemetrexed or carboplatin plus paclitaxel in patients with lung cancer: A propensity score-matched analysis.BMC Cancer20212117410.1186/s12885‑021‑07802‑y 33451299
     [Google Scholar]
  27. HuC. LiT. XuY. ZhangX. LiF. BaiJ. ChenJ. JiangW. YangK. OuQ. LiX. WangP. ZhangY. CellMarker 2.0: An updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data.Nucleic Acids Res.202351D1D870D87610.1093/nar/gkac947 36300619
     [Google Scholar]
  28. JinS. Guerrero-JuarezC.F. ZhangL. ChangI. RamosR. KuanC.H. MyungP. PlikusM.V. NieQ. Inference and analysis of cell-cell communication using cell chat.Nat. Commun.2021121108810.1038/s41467‑021‑21246‑9 33597522
     [Google Scholar]
  29. MengX. KuangH. WangQ. ZhangH. WangD. KangT. A polysaccharide from Codonopsis pilosula roots attenuates carbon tetrachloride-induced liver fibrosis via modulation of TLR4/NF-κB and TGF-β1/Smad3 signaling pathway.Int. Immunopharmacol.202311911018010.1016/j.intimp.2023.110180 37068337
     [Google Scholar]
  30. ZouY. YanH. LiC. WenF. JizeX. ZhangC. A pectic polysaccharide from Codonopsis pilosula alleviates inflammatory response and oxidative stress of aging mice via modulating intestinal microbiota-related gut-liver axis.Antioxidants2023129178110.3390/antiox12091781
     [Google Scholar]
  31. ZickS.M. RuffinM.T. LeeJ. NormolleD.P. SidenR. AlrawiS. Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting.Support. Care Cancer200917556357210.1007/s00520‑008‑0528‑8
     [Google Scholar]
  32. PanahiY. SaadatA. SahebkarA. HashemianF. TaghikhaniM. AbolhasaniE. Effect of ginger on acute and delayed chemotherapy-induced nausea and vomiting: A pilot, randomized, open-label clinical trial.Integr. Cancer Ther.201211320421110.1177/1534735411433201 22313739
     [Google Scholar]
  33. LvS. WangQ. ZhangX. NingF. LiuW. CuiM. XuY. Mechanisms of multi-omics and network pharmacology to explain traditional chinese medicine for vascular cognitive impairment: A narrative review.Phytomedicine202412315523110.1016/j.phymed.2023.155231 38007992
     [Google Scholar]
  34. GuoS.B. MengY. LinL. ZhouZ.Z. LiH.L. TianX.P. HuangW.J. Artificial intelligence alphafold model for molecular biology and drug discovery: A machine-learning-driven informatics investigation.Mol. Cancer202423122310.1186/s12943‑024‑02140‑6 39369244
     [Google Scholar]
  35. ZhangL. ZhengY. ShaoM. ChenA. LiuM. SunW. LiT. FangY. DongY. ZhaoS. LuoH. FengJ. WangQ. LiL. ZhengY. AlphaFold-based AI docking reveals AMPK/SIRT1-TFEB pathway modulation by traditional Chinese medicine in metabolic-associated fatty liver disease.Pharmacol. Res.202521210761710.1016/j.phrs.2025.107617 39832686
     [Google Scholar]
/content/journals/acamc/10.2174/0118715206427314251002153843
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Jianpi Yiwei Granules for Chemotherapy-Induced Gastrointestinal Reactions: A Randomized Double-Blind Placebo-Controlled Trial
Anti-Cancer Agents in Medicinal Chemistry 26, 217 (2026); https://doi.org/10.2174/0118715206427314251002153843
/content/journals/acamc/10.2174/0118715206427314251002153843
/content/journals/acamc/10.2174/0118715206427314251002153843
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  • Article Type:     Research Article
Keyword(s): chemotherapy-induced gastrointestinal reactions; double-blind randomized placebo-controlled trial; Jianpi Yiwei Granules; non-small cell lung cancer; protocol; Traditional Chinese medicine

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