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image of Camel Milk in Skin Cancer Therapeutics: An In-vitro and In-vivo Study

Abstract

Introduction

Therapeutic applications of camel milk in various human ailments have led to the investigation of camel milk against multiple cancers. However, the absence of its scientific evidence in skin cancer protection has prompted this new study’s inception.

Methods

The study includes estimation of camel milk’s chemo-preventive potential on A431 cells and a two-stage skin carcinogenesis model ( The studies included MTT, scratch and flow cytometry assay to determine the anti-proliferative effects, anti-migratory ability and cell numbers in various cell cycle stages. In the study, estimations of tumour morphology, biochemical alterations, along with a histopathological study were performed. Further, the milk was assessed for its anti-oxidative activities, followed by GC-MS analysis for the investigation of potential compounds.

Results

The results demonstrated camel milk’s dose-dependent anti-proliferation, significant (0.001) cell migration inhibition, and conclusive G1/S phase cell cycle arrest. The study revealed a notable reduction in tumour parameters and histopathological lesions in skin and liver tissues of camel milk-treated mice. Additionally, a marked decrease (0.005; 0.001) in LPO levels and an increase in GSH, catalase and SOD biochemical parameters were noted. Moreover, dose-dependent elevation (0.001) of milk’s anti-oxidative activity (DPPH, ABTS, ferrous-ion & superoxide-anion chelating) and presence of numerous anti-oxidative and anti-cancer compounds was observed.

Discussions

The investigation highlights translational relevance of camel milk's outcomes as supported by findings. Moreover, GC-MS analysis and anti-oxidative potential underscore the mechanism behind the observed chemo-prevention.

Conclusions

The study reveals camel milk’s significant chemo-preventive efficacy primarily due to its robust antioxidant properties, making it a promising adjunct skin cancer therapy.

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2025-10-20
2025-12-14

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/content/journals/acamc/10.2174/0118715206409156251001091047
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Camel Milk in Skin Cancer Therapeutics: An In-vitro and In-vivo Study
Bentham Science Publishers ; https://doi.org/10.2174/0118715206409156251001091047
/content/journals/acamc/10.2174/0118715206409156251001091047
/content/journals/acamc/10.2174/0118715206409156251001091047
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  • Article Type:     Research Article
Keywords: skin cancer therapy ; anti-proliferative ; two-stage skin carcinogenesis ; antioxidants ; Camel milk ; A431 cells

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