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image of Natural Combatants: How Herbal Monomers Regulate Autophagy in Ovarian Cancer
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Abstract

Introduction

Ovarian cancer (OC) is a lethal gynecological malignancy, with current therapies constrained by drug resistance and side effects. Autophagy plays a dual role in OC, while Traditional Chinese Medicine (TCM) monomers, as natural bioactive compounds, demonstrate significant potential in regulating autophagy and combating tumors. This review aims to summarize the mechanisms by which TCM monomers regulate autophagy in OC, providing a theoretical basis for TCM-based drug development and clinical applications.

Methods

Relevant literature was retrieved from databases including PubMed, Web of Science, and CNKI. The action targets and signaling pathways of TCM monomers were summarized to elucidate their mechanisms in regulating OC autophagy.

Results

TCM monomers (, ginsenoside Rg3, curcumin) bidirectionally regulate OC autophagy through pathways such as PI3K/AKT/mTOR and MAPK; some enhance chemotherapy sensitivity by inducing excessive autophagy or inhibiting protective autophagy.

Discussion

TCM monotherapy offers unique advantages in the treatment of OC through precise regulation of autophagy. However, most studies are limited to experiments, and there is insufficient efficacy and clinical translational evidence.

Conclusion

Validating the complex action network of TCM monomers through multi-omics and clinical studies, and exploring their synergistic effects with conventional chemotherapy, is crucial for advancing the development of natural anti-ovarian cancer drugs.

© 2026 The Author(s). Published by Bentham Science Publishers.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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2026-02-13
2026-02-27

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References

  1. Cao W. Chen H.D. Yu Y.W. Li N. Chen W.Q. Changing profiles of cancer burden worldwide and in China: A secondary analysis of the global cancer statistics 2020. Chin Med. J. 2021 134 7 783 791 10.1097/CM9.0000000000001474 33734139
    [Google Scholar]
  2. Webb P.M. Jordan S.J. Global epidemiology of epithelial ovarian cancer. Nat. Rev. Clin. Oncol. 2024 21 5 389 400 10.1038/s41571‑024‑00881‑3 38548868
    [Google Scholar]
  3. Chien J. Poole E.M. Ovarian cancer prevention, screening, and early detection: Report from the 11th biennial ovarian cancer research symposium. Int. J. Gynecol. Cancer 2017 27 9S S20 S22 (Suppl. 5) 10.1097/IGC.0000000000001118 29278600
    [Google Scholar]
  4. Webb P.M. Jordan S.J. Epidemiology of epithelial ovarian cancer. Best Pract. Res. Clin. Obstet. Gynaecol. 2017 41 3 14 10.1016/j.bpobgyn.2016.08.006 27743768
    [Google Scholar]
  5. Havasi A. Cainap S.S. Havasi A.T. Cainap C. Ovarian cancer— insights into platinum resistance and overcoming it. Medicina 2023 59 3
    [Google Scholar]
  6. Mizushima N. Levine B. Autophagy in human diseases. N Engl J. Med. 2020 383 16 1564 1576 10.1056/NEJMra2022774 33053285
    [Google Scholar]
  7. Ma X. Hu M. Wang H. Li J. Discovery of traditional Chinese medicine monomers and their synthetic intermediates, analogs or derivatives for battling P-gp-mediated multi-drug resistance. Eur J. Med. Chem. 2018 159 381 392 10.1016/j.ejmech.2018.09.061 30308411
    [Google Scholar]
  8. Levy J.M.M. Towers C.G. Thorburn A. Targeting autophagy in cancer. Nat. Rev. Cancer 2017 17 9 528 542 10.1038/nrc.2017.53 28751651
    [Google Scholar]
  9. Wang S.F. Wu M.Y. Cai C.Z. Li M. Lu J.H. Autophagy modulators from traditional Chinese medicine: Mechanisms and therapeutic potentials for cancer and neurodegenerative diseases. J. Ethnopharmacol 2016 194 861 876 10.1016/j.jep.2016.10.069 27793785
    [Google Scholar]
  10. Thorburn A. Thamm D.H. Gustafson D.L. Autophagy and cancer therapy. Mol. Pharmacol. 2014 85 6 830 838 10.1124/mol.114.091850 24574520
    [Google Scholar]
  11. Orlikova B. Legrand N. Panning J. Dicato M. Diederich M. Anti-inflammatory and anticancer drugs from nature. Advances in Nutrition and Cancer 159. Zappia V. Panico S. Russo G.L. Budillon A. Della Ragione F. Berlin, Heidelberg Springer Berlin Heidelberg 2014 123 143 10.1007/978‑3‑642‑38007‑5_8
    [Google Scholar]
  12. Yang MH Liu Y Kong LY The innovative drug research base on effective monomer compositions from traditional Chinese medicine. World Science and Technology/Modernization of Traditional Chinese Medicine and Materia Medica 2016 18 3 329 336
    [Google Scholar]
  13. Ashford T.P. Porter K.R. Cytoplasmic components in hepatic cell lysosomes. J. Cell. Biol. 1962 12 1 198 202 10.1083/jcb.12.1.198 13862833
    [Google Scholar]
  14. Galluzzi L. Baehrecke E.H. Ballabio A. Boya P. Bravo-San Pedro J.M. Cecconi F. Choi A.M. Chu C.T. Codogno P. Colombo M.I. Cuervo A.M. Debnath J. Deretic V. Dikic I. Eskelinen E.L. Fimia G.M. Fulda S. Gewirtz D.A. Green D.R. Hansen M. Harper J.W. Jäättelä M. Johansen T. Juhasz G. Kimmelman A.C. Kraft C. Ktistakis N.T. Kumar S. Levine B. Lopez-Otin C. Madeo F. Martens S. Martinez J. Melendez A. Mizushima N. Münz C. Murphy L.O. Penninger J.M. Piacentini M. Reggiori F. Rubinsztein D.C. Ryan K.M. Santambrogio L. Scorrano L. Simon A.K. Simon H.U. Simonsen A. Tavernarakis N. Tooze S.A. Yoshimori T. Yuan J. Yue Z. Zhong Q. Kroemer G. Molecular definitions of autophagy and related processes. EMBO J. 2017 36 13 1811 1836 10.15252/embj.201796697 28596378
    [Google Scholar]
  15. Towers C.G. Wodetzki D. Thorburn A. Autophagy and cancer: Modulation of cell death pathways and cancer cell adaptations. J. Cell. Biol. 2020 219 1 e201909033 31753861
    [Google Scholar]
  16. Onorati A.V. Dyczynski M. Ojha R. Amaravadi R.K. Targeting autophagy in cancer. Cancer 2018 124 16 3307 3318 10.1002/cncr.31335 29671878
    [Google Scholar]
  17. Ma X. Wu Y. Cao G. S100A8 Mediates autophagy and apoptosis in ovarian cancer cells via the PI3K/Akt Pathway. Discov Med. 2025 37 197 1117 1129 10.24976/Discov.Med.202537197.99 40485527
    [Google Scholar]
  18. Al-Odat O.S. Guirguis D.A. Schmalbach N.K. Yao G. Budak-Alpdogan T. Jonnalagadda S.C. Pandey M.K. Autophagy and apoptosis: Current challenges of treatment and drug resistance in multiple myeloma. Int. J. Mol. Sci. 2022 24 1 644 10.3390/ijms24010644 36614089
    [Google Scholar]
  19. Gao X. Yin Q. Wang Z. Olaparib Triggers Mitochondrial Fission Through the CDK5/Drp‐1 Signaling Pathway in Ovarian Cancer Cells. J. Biochem. Mol. Toxicol. 2025 39 6 e70273 10.1002/jbt.70273 40384022
    [Google Scholar]
  20. Ishaq M. Ojha R. Sharma A.P. Singh S.K. Autophagy in cancer: Recent advances and future directions. Semin Cancer Biol. 2020 66 171 181 10.1016/j.semcancer.2020.03.010 32201367
    [Google Scholar]
  21. Amaravadi R.K. Kimmelman K.C. Debnath J. Targeting autophagy in cancer: Recent advances and future directions. Cancer Discov. 2019 9 9 1167 1181 10.1158/2159‑8290.CD‑19‑0292 31434711
    [Google Scholar]
  22. Zhu J. Zhu H. Zhu Q. Xu S.L. Xiao L. Zhang M.Y. Gao J. The roles of autophagy, ferroptosis and pyroptosis in the anti-ovarian cancer mechanism of harmine and their crosstalk. Sci. Rep 2024 14 1 6504 10.1038/s41598‑024‑57196‑7 38499622
    [Google Scholar]
  23. Nokhostin F. Azadehrah M. Azadehrah M. The multifaced role and therapeutic regulation of autophagy in ovarian cancer. Clin. Transl. Oncol. 2022 25 5 1207 1217 10.1007/s12094‑022‑03045‑w 36534371
    [Google Scholar]
  24. Takeda T. Komatsu M. Chiwaki F. Komatsuzaki R. Nakamura K. Tsuji K. Kobayashi Y. Tominaga E. Ono M. Banno K. Aoki D. Sasaki H. Upregulation of IGF2R evades lysosomal dysfunction-induced apoptosis of cervical cancer cells via transport of cathepsins. Cell. Death Dis. 2019 10 12 876 10.1038/s41419‑019‑2117‑9 31748500
    [Google Scholar]
  25. Ye R. Dai N. He Q. Guo P. Xiang Y. Zhang Q. Hong Z. Zhang Q. Comprehensive anti-tumor effect of Brusatol through inhibition of cell viability and promotion of apoptosis caused by autophagy via the PI3K/Akt/mTOR pathway in hepatocellular carcinoma. Biomed. Pharmacother. 2018 105 962 973 10.1016/j.biopha.2018.06.065 30021391
    [Google Scholar]
  26. Meng C.Y. Zhao Z.Q. Bai R. Zhao W. Wang Y.X. Xue H.Q. Sun L. Sun C. Feng W. Guo S.B. MicroRNA-22 mediates the cisplatin resistance of osteosarcoma cells by inhibiting autophagy via the PI3K/Akt/mTOR pathway. Oncol. Rep. 2020 43 4 1169 1186 10.3892/or.2020.7492 32323781
    [Google Scholar]
  27. Cui Z.Y. Jo E. Jang H.J. Hwang I.H. Lee K.B. Yoo H.S. Park S.J. Jung M.K. Lee Y.W. Jang I.S. Modified ginseng extract induces apoptosis in HepG2 cancer cells by blocking the CXCL8-mediated akt/nuclear factor-κB signaling pathway. Am J. Chin Med. 2018 46 7 1645 1662 10.1142/S0192415X18500842 30284465
    [Google Scholar]
  28. Yoshikawa T. Miyamoto M. Aoyama T. Soyama H. Goto T. Hirata J. Suzuki A. Nagaoka I. Tsuda H. Furuya K. Takano M. JAK2/STAT3 pathway as a therapeutic target in ovarian cancers. Oncol. Lett 2018 15 4 5772 5780 10.3892/ol.2018.8028 29545902
    [Google Scholar]
  29. You L. Wang Z. Li H. Shou J. Jing Z. Xie J. Sui X. Pan H. Han W. The role of STAT3 in autophagy. Autophagy 2015 11 5 729 739 10.1080/15548627.2015.1017192 25951043
    [Google Scholar]
  30. Lim V. Zhu H. Diao S. Hu L. Hu J. PKP3 interactions with MAPK-JNK-ERK1/2-mTOR pathway regulates autophagy and invasion in ovarian cancer. Biochem. Biophys. Res. Commun 2019 508 2 646 653 10.1016/j.bbrc.2018.11.163 30527804
    [Google Scholar]
  31. Li X. He S. Ma B. Autophagy and autophagy-related proteins in cancer. Mol. Cancer 2020 19 1 12 10.1186/s12943‑020‑1138‑4 31969156
    [Google Scholar]
  32. Zhu X. Ji M. Han Y. Guo Y. Zhu W. Gao F. Yang X. Zhang C. PGRMC1-dependent autophagy by hyperoside induces apoptosis and sensitizes ovarian cancer cells to cisplatin treatment. Int. J. Oncol. 2017 50 3 835 846 10.3892/ijo.2017.3873 28197632
    [Google Scholar]
  33. Liu H. Zhou L.L. Wei D.D. Salidroside down-regulates KRT17 and increases the sensitivity of paclitaxel to chemotherapy in ovarian cancer cells. J. Tianjin Univ Tradit Chin Med. 2022 41 5 625 629
    [Google Scholar]
  34. Cao W. Li J. Yang K. Cao D. An overview of autophagy: Mechanism, regulation and research progress. Bull. Cancer 2021 108 3 304 322 10.1016/j.bulcan.2020.11.004 33423775
    [Google Scholar]
  35. Debnath J. Gammoh N. Ryan K.M. Autophagy and autophagy related pathways in cancer. Nat. Rev. Mol. Cell. Biol. 2023 24 8 560 575 10.1038/s41580‑023‑00585‑z 36864290
    [Google Scholar]
  36. Ferro F. Servais S. Besson P. Roger S. Dumas J.F. Brisson L. Autophagy and mitophagy in cancer metabolic remodelling. Semin Cell. Dev. Biol. 2020 98 129 138 10.1016/j.semcdb.2019.05.029 31154012
    [Google Scholar]
  37. Hu X. Wang J. Chai J. Yu X. Zhang Y. Feng Y. Qin J. Yu H. Chaetomugilin J enhances apoptosis in human ovarian cancer A2780 cells induced by cisplatin through inhibiting Pink1/parkin mediated mitophagy. OncoTargets Ther. 2020 13 9967 9976 10.2147/OTT.S273435 33116582
    [Google Scholar]
  38. Peng C. Guo Y. Yu Y. Liu F.Y. Han F.J. Role of autophagy in ovarian cancer based on yin and yang theory. Zhongguo Shiyan Fangjixue Zazhi 2024 30 16 185 192
    [Google Scholar]
  39. Singh S.S. Vats S. Chia A.Y.Q. Tan T.Z. Deng S. Ong M.S. Arfuso F. Yap C.T. Goh B.C. Sethi G. Huang R.Y.J. Shen H.M. Manjithaya R. Kumar A.P. Dual role of autophagy in hallmarks of cancer. Oncogene 2018 37 9 1142 1158 10.1038/s41388‑017‑0046‑6 29255248
    [Google Scholar]
  40. Kocaturk N.M. Akkoc Y. Kig C. Bayraktar O. Gozuacik D. Kutlu O. Autophagy as a molecular target for cancer treatment. Eur J. Pharm. Sci. 2019 134 116 137 10.1016/j.ejps.2019.04.011 30981885
    [Google Scholar]
  41. Chang H. Zou Z. Targeting autophagy to overcome drug resistance: Further developments. J. Hematol. Oncol. 2020 13 1 159 10.1186/s13045‑020‑01000‑2 33239065
    [Google Scholar]
  42. Bai Z. Peng Y. Ye X. Liu Z. Li Y. Ma L. Autophagy and cancer treatment: Four functional forms of autophagy and their therapeutic applications. J. Zhejiang Univ Sci. B 2022 23 2 89 101 10.1631/jzus.B2100804 35187884
    [Google Scholar]
  43. Yang P. Song R. Li N. Sun K. Shi F. Liu H. Shen F. Jiang S. Zhang L. Jin Y. Silica dust exposure induces autophagy in alveolar macrophages through switching Beclin1 affinity from Bcl‐2 to PIK3C3. Environ. Toxicol. 2020 35 7 758 767 10.1002/tox.22910 32061152
    [Google Scholar]
  44. Mauthe M. Orhon I. Rocchi C. Zhou X. Luhr M. Hijlkema K.J. Coppes R.P. Engedal N. Mari M. Reggiori F. Chloroquine inhibits autophagic flux by decreasing autophagosome lysosome fusion. Autophagy 2018 14 8 1435 1455 10.1080/15548627.2018.1474314 29940786
    [Google Scholar]
  45. Luo D. He F. Liu J. Dong X. Fang M. Liang Y. Chen M. Gui X. Wang W. Zeng L. Fan X. Wu Q. Pseudolaric acid B suppresses NSCLC progression through the ROS/AMPK/mTOR/autophagy signalling pathway. Biomed. Pharmacother 2024 175 116614 10.1016/j.biopha.2024.116614 38670047
    [Google Scholar]
  46. Wang J.H. Wang N. Yuan L.L. Autophagy of ovarian cancer HO-8910 cells induced by pseudolaric acid-B and its mechanism. Shiyong Yaowu Yu Linchuang 2020 23 9
    [Google Scholar]
  47. Wang H. Luo Y. Chu Z. Ni T. Ou S. Dai X. Zhang X. Liu Y. Poria Acid, Triterpenoids Extracted from Poria cocos, Inhibits the Invasion and Metastasis of Gastric Cancer Cells. Molecules 2022 27 11 3629 10.3390/molecules27113629 35684565
    [Google Scholar]
  48. Ma R. Zhang Z. Xu J. Liang X. Zhao Q. Poricoic acid A induces apoptosis and autophagy in ovarian cancer via modulating the mTOR/p70s6k signaling axis. Braz J. Med. Biol. Res. 2021 54 12 e11183 10.1590/1414‑431x2021e11183 34669780
    [Google Scholar]
  49. Guo H.M. Wang G. Li N. Sun H. Zhang Y.F. Antitumor effect and mechanism of Triptolide. Progress of Anatomical Sciences 2020 26 6 731 734
    [Google Scholar]
  50. Zhong YY Study on the mechanism of triptolide regulating JAK2/STAT3/Mcl-1 autophagic pathway against cisplatin-resistant epithelial ovarian cancer.. Nanchang University 2021
    [Google Scholar]
  51. Zhong Y. Le F. Cheng J. Luo C. Zhang X. Wu X. Xu F. Zuo Q. Tan B. Triptolide inhibits JAK2/STAT3 signaling and induces lethal autophagy through ROS generation in cisplatin-resistant SKOV3/DDP ovarian cancer cells. Oncol. Rep 2021 45 5 69 10.3892/or.2021.8020 33760192
    [Google Scholar]
  52. Zhang X. Xie L. Long J. Xie Q. Zheng Y. Liu K. Li X. Salidroside: A review of its recent advances in synthetic pathways and pharmacological properties. Chem. Biol. Interact. 2021 339 109268 10.1016/j.cbi.2020.109268 33617801
    [Google Scholar]
  53. Lu D Zhang HF Wang YY Research progress on antitumor and antiviral pharmacological effects of stephanine. Guangxi Medicine 2023 45 4 465 468
    [Google Scholar]
  54. Xiang F.Y. Jiang S.L. Cheng X.Y. Cepharanthine induces autophagy via PI3K/AKT/mTOR signaling path-way in ovarian cancer SKOV3 cells. Chinese Journal of Pathophysiology 2019 35 5 940 944
    [Google Scholar]
  55. Liu T. Liu X. Li W. Tetrandrine, a Chinese plant-derived alkaloid, is a potential candidate for cancer chemotherapy. Oncotarget 2016 7 26 40800 40815 10.18632/oncotarget.8315 27027348
    [Google Scholar]
  56. Shen T.L. Chen M.J. Li Y.Y. Li F. Tetrandrine induces autophagy of ovarian cancer cells by inhibitingPI3K/Akt/mTOR signaling pathway. Chin. J. Pathophysiol. 2020 36 8 1428 1433
    [Google Scholar]
  57. Xu J.Y. Guo Y. Yang S. Han F.J. Study progress of effect of traditional Chinese medicine monomer in intervening ovarian cancer by regulating PI3K/Akt signaling pathway. Zhongguo Shiyan Fangjixue Zazhi 2021 27 8 218 227
    [Google Scholar]
  58. Zhang X. Hou G. Liu A. Xu H. Guan Y. Wu Y. Deng J. Cao X. Matrine inhibits the development and progression of ovarian cancer by repressing cancer associated phosphorylation signaling pathways. Cell. Death Dis. 2019 10 10 770 10.1038/s41419‑019‑2013‑3 31601793
    [Google Scholar]
  59. Zhang M.F. Wang J.X. Shen Y.Q. Research advances of matrine against mammary cancer and ovarian carcinoma. Yaowu Pingjia Yanjiu 2019 42 10 2111 2118
    [Google Scholar]
  60. Zhang L. Li D. Yu S. Pharmacological effects of harmine and its derivatives: A review. Arch. Pharm. Res. 2020 43 12 1259 1275 10.1007/s12272‑020‑01283‑6 33206346
    [Google Scholar]
  61. Marthandam Asokan S. Mariappan R. Muthusamy S. Velmurugan B.K. Pharmacological benefits of neferine - A comprehensive review. Life. Sci. 2018 199 60 70 10.1016/j.lfs.2018.02.032 29499283
    [Google Scholar]
  62. Xu L. Zhang X. Li Y. Lu S. Shan L. Li J. Wang Y. Tian X. Wei J. Shao C. Liu Z. Neferine induces autophagy of human ovarian cancer cells via p38 MAPK/JNK activation. Tumour Biol. 2016 37 7 8721 8729 10.1007/s13277‑015‑4737‑8 26738868
    [Google Scholar]
  63. Guo X.X. Zhao L.N. Wang J. Liu S. Bi Q.R. Wang Z. Tan N.H. [Chemical constituents from root barks of Dictamnus dasycarpus and their cytotoxic activities]. Zhongguo Zhongyao Zazhi 2018 43 24 4869 4877 30717533
    [Google Scholar]
  64. Lv S.H. Liang J.L. Deng M.J. Liu Y.Z. Wang Q. Dictamnine inhibits proliferation and induces autophage and apoptosis by targeting PI3K/KEAP1 signaling in ovarian cancer cells. Chin J. of Oncol. Prev. and Trea. 2023 15 3 285 291
    [Google Scholar]
  65. Zhang Y. Qiu Y.K. Chen J.Y. Bo K.N. Jiang Y.T. Pei Y.H. Chemical constituents of Bufo bufo gargarizans skin. J. Shenyang Pharm. Univ 2007 8 484 487
    [Google Scholar]
  66. Gong Q Liu Y. Research on ROS induced apoptosis and mitophagy stimulated by 19-Hydroxytelocinobufagin (19-HTBG) in ovarian cancer cells.. Zunyi Medical University 2020
    [Google Scholar]
  67. Zhang Y.M. Li T. Xu C.C. Qian J.Y. Guo H. Zhang X. Zhan Z.J. Lu J.J. Uncover the anticancer potential of lycorine. Chin. Med. 2024 19 1 121 10.1186/s13020‑024‑00989‑9 39245716
    [Google Scholar]
  68. Hu XM The research application of endoscopic monitor in the hysteroscope operation; Lycorine induces apoptosis and autophagy, decreases invasion and migration in ovarian cancer and breast cancer. Lanzhou, China Lanzhou University 2017
    [Google Scholar]
  69. Rui Z. Chang-Pei X. Jing-Jing Z. Hong-Jun Y. [Research progress on chemical compositions of Coptidis Rhizoma and pharmacological effects of berberine]. Zhongguo Zhongyao Zazhi 2020 45 19 4561 4573 33164419
    [Google Scholar]
  70. Li SY Yu Y Liu SB Effect of berberine on endoplasmic reticulum stress-autophagy pathway in human ovarian cancer SKOV3 cells. Chin. J. Pathophysiol. 2019 35 10 1869 1873
    [Google Scholar]
  71. Yan X. Yuan C. Wang Z. Xu Z. Wu Z. Wang M. Xu M. Zuang W. Sun Y. Berberine modulates ovarian cancer autophagy and glycolysis through the LINC01123/P65/MAPK10 signaling axis. Phytomedicine 2024 135 156121 10.1016/j.phymed.2024.156121 39395322
    [Google Scholar]
  72. Chen M. Xiao J. El-Seedi H.R. Woźniak K.S. Daglia M. Little P.J. Weng J. Xu S. Kaempferol and atherosclerosis: From mechanism to medicine. Crit. Rev. Food. Sci. Nutr. 2024 64 8 2157 2175 10.1080/10408398.2022.2121261 36099317
    [Google Scholar]
  73. El-Kott A.F. Shati A.A. Al-Kahtani M.A. Alharbi S.A. Kaempferol induces cell death in A2780 ovarian cancer cells and increases their sensitivity to cisplatin by activation of cytotoxic endoplasmic reticulum-mediated autophagy and inhibition of protein kinase B. Folia Biol. (Praha) 2020 66 1 36 46 10.14712/fb2020066010036 32512657
    [Google Scholar]
  74. Ren B. Kwah M.X.Y. Liu C. Ma Z. Shanmugam M.K. Ding L. Xiang X. Ho P.C.L. Wang L. Ong P.S. Goh B.C. Resveratrol for cancer therapy: Challenges and future perspectives. Cancer Lett. 2021 515 63 72 10.1016/j.canlet.2021.05.001 34052324
    [Google Scholar]
  75. Wang H. Peng Y. Wang J. Gu A. Li Q. Mao D. Guo L. Effect of autophagy on the resveratrol‐induced apoptosis of ovarian cancer SKOV3 cells. J. Cell. Biochem. 2019 120 5 7788 7793 10.1002/jcb.28053 30450764
    [Google Scholar]
  76. Lang F. Qin Z. Li F. Zhang H. Fang Z. Hao E. Apoptotic cell death induced by resveratrol is partially mediated by the autophagy pathway in human ovarian cancer cells. PLoS One 2015 10 6 e0129196 10.1371/journal.pone.0129196 26067645
    [Google Scholar]
  77. Cadena-Iñiguez J. Santiago-Osorio E. Sánchez-Flores N. Salazar-Aguilar S. Soto-Hernández R.M. Riviello-Flores M.L. Macías-Zaragoza V.M. Aguiñiga-Sánchez I. The cancer-protective potential of protocatechuic acid: A narrative review. Molecules 2024 29 7 1439 10.3390/molecules29071439 38611719
    [Google Scholar]
  78. Xie Z. Guo Z. Wang Y. Lei J. Yu J. Protocatechuic acid inhibits the growth of ovarian cancer cells by inducing apoptosis and autophagy. Phytother Res. 2018 32 11 2256 2263 10.1002/ptr.6163 30047559
    [Google Scholar]
  79. Lu G. Wang X. Cheng M. Wang S. Ma K. The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art. Biomed. Pharmacother. 2023 165 115132 10.1016/j.biopha.2023.115132 37423169
    [Google Scholar]
  80. Elsaid F.G. Alshehri M.A. Shati A.A. Al-Kahtani M.A. Alsheri A.S. Massoud E.E. El-kott A.F. El-Mekkawy H.I. Al-Ramlawy A.M. Abdraboh M.E. The anti‐tumourigenic effect of ellagic acid in SKOV‐3 ovarian cancer cells entails activation of autophagy mediated by inhibiting Akt and activating AMPK. Clin. Exp. Pharmacol. Physiol. 2020 47 9 1611 1621 10.1111/1440‑1681.13338 32415699
    [Google Scholar]
  81. Tanko A.I. Hosawi S. Moglad E. Afzal M. Ghaboura N. Alzareaa S.I. Osman A. Nadeem M.S. Kazmi I. Ginsenoside Rg3 in cancer research: Current trends and future prospects - A Review. Curr. Med. Chem. 2025 32 10.2174/0109298673333781240924024342 39817388
    [Google Scholar]
  82. Zheng X. Chen W. Hou H. Li J. Li H. Sun X. Zhao L. Li X. Ginsenoside 20(S)-Rg3 induced autophagy to inhibit migration and invasion of ovarian cancer. Biomed. Pharmacother. 2017 85 620 626 10.1016/j.biopha.2016.11.072 27899249
    [Google Scholar]
  83. Jung W.Y. Kim H. Jeon S.J. Park H.J. Choi H.J. Kim N.J. Kim D.H. Jang D.S. Ryu J.H. Eclalbasaponin II ameliorates the cognitive impairment induced by cholinergic blockade in mice. Neurochem Res. 2018 43 2 351 362 10.1007/s11064‑017‑2430‑6 29164430
    [Google Scholar]
  84. Cho Y.J. Woo J.H. Lee J.S. Jang D.S. Lee K.T. Choi J.H. Eclalbasaponin II induces autophagic and apoptotic cell death in human ovarian cancer cells. J. Pharmacol. Sci. 2016 132 1 6 14 10.1016/j.jphs.2016.02.006 27032907
    [Google Scholar]
  85. Wang L. Pan G. Tian S. Zhang C. Tao F. Qin J.J. Macranthoside B. Macranthoside B suppresses the growth of adenocarcinoma of esophagogastric junction by regulating iron homeostasis and ferroptosis through NRF2 inhibition. Curr. Cancer Drug Targets. 2025 25 8 1133 1147 10.2174/0115680096370291250109103853 39844412
    [Google Scholar]
  86. Shan Y. Guan F. Zhao X. Wang M. Chen Y. Wang Q. Feng X. Macranthoside B induces apoptosis and autophagy via reactive oxygen species accumulation in human ovarian cancer A2780 cells. Nutr. Cancer 2016 68 2 280 289 10.1080/01635581.2016.1142587 26943028
    [Google Scholar]
  87. Tian Y. Gong G.Y. Ma L.L. Wang Z.Q. Song D. Fang M.Y. Anti-cancer effects of Polyphyllin I: An update in 5 years. Chem. Biol. Interact. 2020 316 108936 10.1016/j.cbi.2019.108936 31870841
    [Google Scholar]
  88. Chen DW Huang JZ Inhibitory effect and preliminary mechanism of chinese herbal monomelic polyphyllin I On Ovarian Cancer Cell SKOV3 and ID8.. Guangdong Medical University 2022
    [Google Scholar]
  89. Wu ZY Huang JZ PolyphyllinI on Ishikawa and Skov3 cells by autophagy.. Guangdong Medical University 2022
    [Google Scholar]
  90. Zhu Y. Lai Y. Pharmacological properties and derivatives of saikosaponins—a review of recent studies. J. Pharm. Pharmacol. 2023 75 7 898 909 10.1093/jpp/rgad052 37307427
    [Google Scholar]
  91. Liu L. Zhang L.F. Fang Z.N. Wang X.Y. Study on the apoptosis of ovarian cancer SKOV 3 cells induced by saikosaponin. China Medical Herald 2017 14 2 25 28
    [Google Scholar]
  92. Zhang L. Liu Y. Lei X. Liu X. Sun H. Liu S. Astragaloside II enhanced sensitivity of ovarian cancer cells to cisplatin via triggering apoptosis and autophagy. Cell. Biol. Int. 2023 47 9 1600 1613 10.1002/cbin.12055 37323083
    [Google Scholar]
  93. Singh D. Singh R. Pharmacological and therapeutic potential of a natural flavonoid icariside II in human complication. Curr. Drug Targets 2025 26 5 320 330 10.2174/0113894501329810241117231839 39757637
    [Google Scholar]
  94. Yuan D. Guo T. Qian H. Ge H. Zhao Y. Huang A. Wang X. Cao X. Zhu D. He C. Yu H. Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR‐144‐3p/IGF2R axis. Drug Dev. Res. 2022 83 6 1383 1393 10.1002/ddr.21967 35808943
    [Google Scholar]
  95. Deng J. Wu T.F. Ye M.Q. Ma Z.G. Cao H. Zhang Y. A comparative identification study on alpiniae katsumadai semen and alpiniae henryi semen. Strait Pharmacy 2023 35 7 22 28
    [Google Scholar]
  96. Shi D. Zhao D. Niu P. Zhu Y. Zhou J. Chen H. Glycolysis inhibition via mTOR suppression is a key step in cardamonin induced autophagy in SKOV3 cells. BMC. Complement. Altern. Med. 2018 18 1 317 10.1186/s12906‑018‑2380‑9 30514289
    [Google Scholar]
  97. Shi D. Niu P. Heng X. Chen L. Zhu Y. Zhou J. Autophagy induced by cardamonin is associated with mTORC1 inhibition in SKOV3 cells. Pharmacol. Rep. 2018 70 5 908 916 10.1016/j.pharep.2018.04.005 30099297
    [Google Scholar]
  98. Ma N. Li Y.J. Fan J.P. Research progress on pharmacological action of diosmetin. Journal of Liaoning University of TCM 2018 20 9 214 217
    [Google Scholar]
  99. Zhang FJ Zhang S.L. Effects and mechanisms of diosmetin on proliferation and apoptosis in ovarian cancer cells... Jilin University 2021
    [Google Scholar]
  100. Zhang RJ Yuan MM. Studies of the anti-tumor effect and mechanism of nobiletin on ovarian cancer.. Southern Medical University 2021
    [Google Scholar]
  101. Jiang Y.P. Guo H. Wang X.B. Nobiletin (NOB) suppresses autophagic degradation via over-expressing AKT pathway and enhances apoptosis in multidrug-resistant SKOV3/TAX ovarian cancer cells. Biomed. Pharmacother. 2018 103 29 37 10.1016/j.biopha.2018.03.126 29635125
    [Google Scholar]
  102. Li R. Zheng C. Shiu P.H.T. Rangsinth P. Wang W. Kwan Y.W. Wong E.S.W. Zhang Y. Li J. Leung G.P.H. Garcinone E triggers apoptosis and cell cycle arrest in human colorectal cancer cells by mediating a reactive oxygen species–dependent JNK signaling pathway. Biomed. Pharmacother. 2023 162 114617 10.1016/j.biopha.2023.114617 37001180
    [Google Scholar]
  103. Xu X.H. Chen Y.C. Xu Y.L. Feng Z.L. Liu Q.Y. Guo X. Lin L-G. Lu J-J. Garcinone E blocks autophagy through lysosomal functional destruction in ovarian cancer cells. World J. Tradit. Chin. Med. 2021 7 2 209 216 10.4103/wjtcm.wjtcm_83_20
    [Google Scholar]
  104. Zhang Y. Ding X. Zhang Q. Zeng C. Chen H. Lu L. Trichosanthin elicits antitumor activity via MICU3 mediated mitochondria calcium influx J. Adv. Res. 2024 S2090-1232 24 00493 4 10.1016/j.jare.2024.11.001 39505142
    [Google Scholar]
  105. Cao C. Qi H. Chen F. He J. Trichosanthin inhibits human ovarian cancer cells growth due to apoptosis and autophagy. Int. J. Clin. Exp. Med. 2017 10 5497 5503
    [Google Scholar]
  106. Zhao T.T. Xu Y.Q. Hu H.M. Gong H.B. Zhu H.L. Isoliquiritigenin (ISL) and its formulations: Potential antitumor agents. Curr. Med. Chem. 2019 26 37 6786 6796 10.2174/0929867325666181112091700 30417769
    [Google Scholar]
  107. Chen H.Y. Huang T.C. Shieh T.M. Wu C.H. Lin L.C. Hsia S.M. Isoliquiritigenin induces autophagy and inhibits ovarian cancer cell growth. Int. J. Mol. Sci. 2017 18 10 2025 10.3390/ijms18102025 28934130
    [Google Scholar]
  108. Kamatou G.P.P. Vermaak I. Viljoen A.M. Lawrence B.M. Menthol: A simple monoterpene with remarkable biological properties. Phytochemistry 2013 96 15 25 10.1016/j.phytochem.2013.08.005 24054028
    [Google Scholar]
  109. Yu Y Liu SB Li SY Xu L Xu Y. Induction effect of myricetin on autophagy in skov3 cells and promoting effect on mitochondrial fission. Journal of Jilin University 2017 43 4 685 689
    [Google Scholar]
  110. Wang Q. Wei H.C. Zhou S.J. Li Y. Zheng T.T. Zhou C.Z. Wan X.H. Hyperoside: A review on its sources, biological activities, and molecular mechanisms. Phytother Res. 2022 36 7 2779 2802 10.1002/ptr.7478 35561084
    [Google Scholar]
  111. Wen Y. Wang Y. Zhao C. Zhao B. Wang J. The Pharmacological Efficacy of Baicalin in Inflammatory Diseases. Int. J. Mol. Sci. 2023 24 11 9317 10.3390/ijms24119317 37298268
    [Google Scholar]
  112. Choi B.Y. Joo J.C. Lee Y.K. Jang I.S. Park S.J. Park Y.J. Anti-cancer effect of Scutellaria baicalensis in combination with cisplatin in human ovarian cancer cell. BMC Complement. Altern. Med. 2017 17 1 277 10.1186/s12906‑017‑1776‑2 28545442
    [Google Scholar]
  113. Mahwish I.M. Imran M. Naeem H. Hussain M. Alsagaby S.A. Al Abdulmonem W. Mujtaba A. Abdelgawad M.A. Ghoneim M.M. El-Ghorab A.H. Selim S. Al Jaouni S.K. Mostafa E.M. Yehuala T.F. Antioxidative and anticancer potential of Luteolin: A comprehensive approach against wide range of human malignancies. Food. Sci. Nutr. 2025 13 1 e4682 10.1002/fsn3.4682 39830909
    [Google Scholar]
  114. Xu R.M. Cao Y.D. Lian X.F. Cai Y. Shi S.J. Zhang S. A2780 cells luteolin-induced apoptosis and autophagy in human ovarian cancer via AKT-mTOR pathway. Hainan Yixueyuan Xuebao 2024 ••• 1 10
    [Google Scholar]
  115. Liu Q. Zhu D. Hao B. Zhang Z. Tian Y. Luteolin promotes the sensitivity of cisplatin in ovarian cancer by decreasing PRPA1-medicated autophagy. Cell. Mol. Biol. 2018 64 6 17 22 10.14715/cmb/2018.64.6.4 29808795
    [Google Scholar]
  116. Zhou A. Peng N. Yang L. Yang S. Wang J. Tanshinone regulated gut microbiota and TMAO to improve high-fat diet induced atherosclerosis in APOE−/− mice. BMC Microbiol. 2025 25 1 432 10.1186/s12866‑025‑04151‑9 40646462
    [Google Scholar]
  117. Li WY Feng C Ren CH Mao YC Zhang ZL Feng H. Effects of Tanshinone IIA on proliferation, migration and autophagy of human ovarian cancer A2780 cells. Journal of Mudanjiang Medical University 2023 44 1 6 9
    [Google Scholar]
  118. Zhang H.L. Luo X.P. Research progress on the biological activity of juglone, the main component of walnut green peel. Med. Chem. Res. 2021 9 164 165
    [Google Scholar]
  119. Zhang J. Ma L.J. Wang Y.H. The effect and mechanism of juglone on autophagy level in human ovarian cancer cell line SKOV3. Zhongguo Yaowu Yu Linchuang 2019 19 18 3091 3092
    [Google Scholar]
  120. García-Vilas J.A. Quesada A.R. Medina M.A. Damnacanthal, a noni anthraquinone, inhibits c-Met and is a potent antitumor compound against Hep G2 human hepatocellular carcinoma cells. Sci. Rep. 2015 5 1 8021 10.1038/srep08021 25620570
    [Google Scholar]
  121. Li R. Li H. Lan J. Yang D. Lin X. Xu H. Han B. Yang M. Su B. Liu F. Jiang W. Damnacanthal isolated from morinda species inhibited ovarian cancer cell proliferation and migration through activating autophagy. Phytomedicine 2022 100 154084 10.1016/j.phymed.2022.154084 35421676
    [Google Scholar]
  122. Qi N. Duan W.J. Li Y.J. Kang S.M. Zhang S.Q. Zhou X.T. Research progress on the pharmacological action of muscone. Modernization of Traditional Chinese Medicine and Materia Materia-World Science and Technology 2020 22 8 3042 3047
    [Google Scholar]
  123. Pan Y. Zhou J. Zhang W. Yan L. Lu M. Dai Y. Zhou H. Zhang S. Yang J. The Sonic Hedgehog signaling pathway regulates autophagy and migration in ovarian cancer. Cancer Med. 2021 10 13 4510 4521 10.1002/cam4.4018 34076346
    [Google Scholar]
  124. Wang A.H. Zhang F.Z. Wang H.Y. Impacts of muscone on malignant progression of ovarian cancer cells by regulating SHH mediated autophagy. Tianjin Yi Yao 2024 52 2
    [Google Scholar]
  125. Zhang X. Chen L.X. Ouyang L. Cheng Y. Liu B. Plant natural compounds: Targeting pathways of autophagy as anti‐cancer therapeutic agents. Cell Prolif. 2012 45 5 466 476 10.1111/j.1365‑2184.2012.00833.x 22765290
    [Google Scholar]
  126. Ning Y Fu YL Zhang QH Zhang C Chen Y. Inhibition of in vitro and in vivo ovarian cancer cell growth by pinoresinol occurs by way of inducing autophagy, inhibition of cell invasion, loss of mitochondrial membrane potential and inhibition ras/MEK/ERK signalling pathway. Journal of BUON: Official journal of the Balkan Union of Oncology 2019 24 2 709 714
    [Google Scholar]
  127. Singh G. Singh M.K. An overview on sources, biosynthesis and bioactivities of osthole: APotential bioactive compound. Curr. Bioact. Compd. 2023 19 8 e210323214828 10.2174/1573407219666230321144827
    [Google Scholar]
  128. Liang J. Zhou J. Xu Y. Huang X. Wang X. Huang W. Li H. Osthole inhibits ovarian carcinoma cells through LC3-mediated autophagy and GSDME-dependent pyroptosis except for apoptosis. Eur J. Pharmacol. 2020 874 172990 10.1016/j.ejphar.2020.172990 32057718
    [Google Scholar]
  129. Guan H.T. Yu C.H. Research progress on anti -tumor mechanism of curcumin. Zhonghua Zhongyiyao Xuekan 2024 42 4 143 151
    [Google Scholar]
  130. Adki K.M. Kulkarni Y.A. Chemistry, pharmacokinetics, pharmacology and recent novel drug delivery systems of paeonol. Life Sci. 2020 250 117544 10.1016/j.lfs.2020.117544 32179072
    [Google Scholar]
  131. Liu L. Pang Y. Zhao X. Li R. Jin C. Xue J. Dong R. Liu P. Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT/mTOR/p70S6K pathway in human ovarian cancer cells. Arch. Gynecol. Obstet. 2019 299 6 1627 1639 10.1007/s00404‑019‑05058‑3 31006841
    [Google Scholar]
  132. Gao L. Wang Z. Lu D. Huang J. Liu J. Hong L. Paeonol induces cytoprotective autophagy via blocking the Akt/mTOR pathway in ovarian cancer cells. Cell Death Dis. 2019 10 8 609 10.1038/s41419‑019‑1849‑x 31406198
    [Google Scholar]
  133. Zhang Z Correlation of autophagy and AKT/mTOR signaling pathway in the reversal of carboplatin resistance in ovarian cancer cells by curcumin.. China Medical University 2018
    [Google Scholar]
  134. Lu Q. Luo S. Shi Z. Yu M. Guo W. Li C. Nitidine chloride, a benzophenanthridine alkaloid from Zanthoxylum nitidum (Roxb.) DC., exerts multiple beneficial properties, especially in tumors and inflammation-related diseases. Front Pharmacol. 2022 13 1046402 10.3389/fphar.2022.1046402 36506558
    [Google Scholar]
  135. Feng F. Zhang J. Lian C. Huang Y. Hu P. Cao Y. Zhang Z. Nitidine chloride triggers autophagy and apoptosis of ovarian cancer cells through Akt/mTOR signaling pathway. Curr. Pharm. Des. 2023 29 19 1524 1534 10.2174/1381612829666230614154847 37317923
    [Google Scholar]
  136. Barras B.J. Ling T. Rivas F. Recent advances in chemistry and antioxidant/anticancer biology of monoterpene and meroterpenoid natural product. Molecules 2024 29 1 279 10.3390/molecules29010279 38202861
    [Google Scholar]
  137. Shi Y.C. He Y. Yang Y. Fan Y.J. Yang F. Zhan L. Chrysin inhibits proliferation and promotes apoptosis of ovarian cancer cells by inducing autophagy. Acta. Universitatis Medicinalis Anhui 2022 57 4 510 514
    [Google Scholar]
  138. Atolani O. Usman M.A. Adejumo J.O. Ayeni A.E. Ibukun O.J. Kola-Mustapha A.T. Njinga N.S. Quadri L.A. Ajani E.O. Amusa T.O. Bakare-Odunola M.T. Oladiji A.T. Alqahtani A. Abbas M. Kambizi L. Isolation, characterization and anti-inflammatory activity of compounds from the Vernonia amygdalina. Heliyon 2024 10 8 e29518 10.1016/j.heliyon.2024.e29518 38665563
    [Google Scholar]
  139. Tu J.H. Lou W.H. Huang R. Zhao A.M. Vernolepin regulates apoptosis and autophagy via microtubule formation in ovarian carcinoma cells. Bangladesh J. Pharmacol. 2015 10 1 100 105 10.3329/bjp.v10i1.21180
    [Google Scholar]
  140. Zhang L Wu J Xue J Jia Z Zhou X Hu G. Investigating the therapeutic potential and molecular mechanisms of daphnetin: A comprehensive review. Recent Patents on Anticancer Drug Discovery 2025 Apr 15; Epub ahead of print.10.2174/0115748928371118250327084127 40237044
    [Google Scholar]
  141. Fan X. Xie M. Zhao F. Li J. Fan C. Zheng H. Wei Z. Ci X. Zhang S. Daphnetin triggers ROS-induced cell death and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway in ovarian cancer. Phytomedicine 2021 82 153465 10.1016/j.phymed.2021.153465 33486268
    [Google Scholar]
  142. Tuli H.S. Aggarwal V. Kaur J. Aggarwal D. Parashar G. Parashar N.C. Tuorkey M. Kaur G. Savla R. Sak K. Kumar M. Baicalein: A metabolite with promising antineoplastic activity. Life Sci. 2020 259 118183 10.1016/j.lfs.2020.118183 32781058
    [Google Scholar]
  143. Wang Y.F. Xu Y.L. Tang Z.H. Li T. Zhang L.L. Chen X. Lu J.H. Leung C.H. Ma D.L. Qiang W.A. Wang Y.T. Lu J.J. Baicalein induces beclin 1-and extracellular signal-regulated kinase-dependent autophagy in ovarian cancer cells. Am. J. Chin. Med. 2017 45 1 123 136 10.1142/S0192415X17500094 28081631
    [Google Scholar]
  144. Yang D. Wang T. Long M. Li P. Quercetin: Its main pharmacological activity and potential application in clinical medicine. Oxid. Med. Cell. Longev. 2020 2020 1 13 10.1155/2020/8825387 33488935
    [Google Scholar]
  145. Liu Y. Gong W. Yang Z.Y. Zhou X.S. Gong C. Zhang T.R. Wei X. Ma D. Ye F. Gao Q.L. Quercetin induces protective autophagy and apoptosis through ER stress via the p-STAT3/Bcl-2 axis in ovarian cancer. Apoptosis 2017 22 4 544 557 10.1007/s10495‑016‑1334‑2 28188387
    [Google Scholar]
  146. Naz I. Ramchandani S. Khan M.R. Yang M.H. Ahn K.S. Anticancer potential of raddeanin a, a natural triterpenoid isolated from anemone raddeana regel. Molecules 2020 25 5 1035 10.3390/molecules25051035 32106609
    [Google Scholar]
  147. Zhao F. Gao Y. Chu X. Chen J. Huang L. Zhao J. Zhang J. Zhao S. ROS attenuates the antitumor effect of Raddeanin on ovarian cancer cells Skov3. Int. J. Clin. Exp. Pathol. 2017 10 8 8292 8302 31966680
    [Google Scholar]
  148. Chu XM The effect and mechanism of ROS in the inhibition of proliferation of Raddeanin A on ovarian cancer cell Skov3.. Jilin University 2015
    [Google Scholar]
  149. Bukowski K. Kciuk M. Kontek R. Mechanisms of multidrug resistance in cancer chemotherapy. Int. J. Mol. Sci. 2020 21 9 3233 10.3390/ijms21093233 32370233
    [Google Scholar]
  150. Li S.H. Chen Y.H. Lv Y. Research progress on autophagy and chemotherapy resistance of cancer. Anti-tumor Pharmacy 2022 12 3 331 336
    [Google Scholar]
  151. Capasso L. De Masi L. Sirignano C. Maresca V. Basile A. Nebbioso A. Rigano D. Bontempo P. Epigallocatechin gallate (EGCG): Pharmacological properties, biological activities and therapeutic potential. Molecules 2025 30 3 654 10.3390/molecules30030654 39942757
    [Google Scholar]
  152. Wang Y. Yin Z.Y. Liu T. Zheng B.B. Zhang J.B. Li Y.Y. Effects of EGCG on the autophagy of human ovarian cancer SKOV3 cells. Journal of Xuzhou Medical University 2016 36 7 436 440
    [Google Scholar]
  153. Teng C. Chen J.W. Shen L.S. Chen S. Chen G.Q. Research advances in natural sesquiterpene lactones: Overcoming cancer drug resistance through modulation of key signaling pathways. Cancer Drug Resist. 2025 8 13 10.20517/cdr.2024.178 40201307
    [Google Scholar]
  154. Xie Z. Study on the mechanism of scutellarin and isoalantolactone in sensitizing ovarian cancer cells to cisplatin.. Wu Han University 2019
    [Google Scholar]
  155. Liang X Inhibition of STX17–SNAP29–VAMP8 complex formation by costunolide sensitizes ovarian cancer cells to cisplatin via the AMPK/mTOR signaling pathway.. North Sichuan Medical College 2023
    [Google Scholar]
  156. Wang Y Wu X Liu FJ Zhang CL Effects of magnoflorine on the migration, invasion and stemness characteristics of lung cancer cells by regulating the CD44s/STAT3 pathway. Shaanxi Medical Journal 2024 53 11 1449 1453
    [Google Scholar]
  157. Zhang Y. He X. Fan L. Zhang Q. Magnoflorine inhibits cisplatin-induced protective autophagy by down-regulating HMGB1 and increases drug sensitivity in drug-resistant ovarian cancer cells. Eur J. Gynaecol Oncol. 2024 45 1 132 138 10.22514/ejgo.2024.018
    [Google Scholar]
  158. Kaur K. Sharma R. Singh A. Attri S. Arora S. Kaur S. Bedi N. Pharmacological and analytical aspects of alkannin/shikonin and their derivatives: An update from 2008 to 2022. Chin Herb Med. 2022 14 4 511 527 10.1016/j.chmed.2022.08.001 36405061
    [Google Scholar]
  159. Fang K. Qiu F. Ding Y.N. Deng D.N. Tan Q.F. Effects of shikonin on ovarian cancer SK- OV- 3 cells through autophagy mediated by keap1/Nrf2Signaling pathway. Zhongyao Xinyao Yu Linchuang Yaoli 2023 34 8 1053 1060
    [Google Scholar]
  160. Wang S. Li J. Xu S. Wang N. Pan B. Yang B. Zheng Y. Zhang J. Peng F. Peng C. Wang Z. Baohuoside I chemosensitises breast cancer to paclitaxel by suppressing extracellular vesicle/CXCL1 signal released from apoptotic cells. J. Extracell. Vesicles 2024 13 7 e12493 10.1002/jev2.12493 39051750
    [Google Scholar]
  161. Zhou Y. Liu T. Wu Q. Wang H. Sun Y. Baohuoside I inhibits resistance to cisplatin in ovarian cancer cells by suppressing autophagy via downregulating HIF‐1α/ATG5 axis. Mol. Carcinog. 2023 62 10 1474 1486 10.1002/mc.23590 37283234
    [Google Scholar]
  162. Cai J. Wen H. Zhou H. Zhang D. Lan D. Liu S. Li C. Dai X. Song T. Wang X. He Y. He Z. Tan J. Zhang J. Naringenin: A flavanone with anti-inflammatory and anti-infective properties. Biomed. Pharmacother 2023 164 114990 10.1016/j.biopha.2023.114990 37315435
    [Google Scholar]
  163. Zhu J. Lin S. Zou X. Chen X. Liu Y. Yang X. Gao J. Zhu H. Mechanisms of autophagy and endoplasmic reticulum stress in the reversal of platinum resistance of epithelial ovarian cancer cells by naringin. Mol. Biol. Rep. 2023 50 8 6457 6468 10.1007/s11033‑023‑08558‑3 37326754
    [Google Scholar]
  164. Wang Y. Liu M. Jia X. Yang Q. Du Y. AMPK/mTOR/ULK1 pathway participates in autophagy induction by curcumin in colorectal adenoma mouse model. Drug Dev. Res. 2025 86 5 e70115 10.1002/ddr.70115 40635394
    [Google Scholar]
  165. Dai L.B. Zhong J.T. Shen L.F. Zhou S.H. Lu Z.J. Bao Y.Y. Fan J. Radiosensitizing effects of curcumin alone or combined with GLUT1 siRNA on laryngeal carcinoma cells through AMPK pathway‐induced autophagy. J. Cell. Mol. Med. 2021 25 13 6018 6031 10.1111/jcmm.16450 33955148
    [Google Scholar]
  166. Kang H.S. Lim H.K. Jang W.Y. Cho J.Y. Anti-colorectal cancer activity of Panax and its active components, ginsenosides: A review. Int. J. Mol. Sci. 2025 26 6 2593 10.3390/ijms26062593 40141242
    [Google Scholar]
  167. Wang L. Zhang Y. Song Z. Liu Q. Fan D. Song X. Ginsenosides: A potential natural medicine to protect the lungs from lung cancer and inflammatory lung disease. Food. Funct. 2023 14 20 9137 9166 10.1039/D3FO02482B 37801293
    [Google Scholar]
  168. Xu J. Hu M. Li Y. Gong H. Zhang X. He Z. Xiao C. Yang C. Zeng J. Berberine enhances the sensitivity of colorectal cancer cells to 5‐FU through smoothing endoplasmic reticulum stress‐mediated autophagic flux. Cell Biol. Int. 2025 49 8 1042 1055 10.1002/cbin.70038 40443360
    [Google Scholar]
  169. Ramesh G. Das S. Bola Sadashiva S.R. Berberine, a natural alkaloid sensitizes human hepatocarcinoma to ionizing radiation by blocking autophagy and cell cycle arrest resulting in senescence. J. Pharm. Pharmacol. 2020 72 12 1893 1908 10.1111/jphp.13354 32815562
    [Google Scholar]
  170. Wei P. Zhang X. Yan C. Sun S. Chen Z. Lin F. Mitochondrial dysfunction and aging: Multidimensional mechanisms and therapeutic strategies. Biogerontology 2025 26 4 142 10.1007/s10522‑025‑10273‑4 40634825
    [Google Scholar]
  171. Kovale L. Singh M.K. Kim J. Ha J. Role of autophagy and ampk in cancer stem cells: Therapeutic opportunities and obstacles in cancer. Int. J. Mol. Sci. 2024 25 16 8647 10.3390/ijms25168647 39201332
    [Google Scholar]
  172. Baird L. Yamamoto M. The molecular mechanisms regulating the KEAP1-NRF2 Pathway. Mol. Cell. Biol. 2020 40 13 e00099 e20 10.1128/MCB.00099‑20 32284348
    [Google Scholar]
  173. Galluzzi L. Pietrocola F. Bravo-San Pedro J.M. Amaravadi R.K. Baehrecke E.H. Cecconi F. Codogno P. Debnath J. Gewirtz D.A. Karantza V. Kimmelman A. Kumar S. Levine B. Maiuri M.C. Martin S.J. Penninger J. Piacentini M. Rubinsztein D.C. Simon H.U. Simonsen A. Thorburn A.M. Velasco G. Ryan K.M. Kroemer G. Autophagy in malignant transformation and cancer progression. EMBO J. 2015 34 7 856 880 10.15252/embj.201490784 25712477
    [Google Scholar]
  174. Patra S. Mishra S.R. Behera B.P. Mahapatra K.K. Panigrahi D.P. Bhol C.S. Praharaj P.P. Sethi G. Patra S.K. Bhutia S.K. Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives. Semin. Cancer Biol. 2022 80 205 217 10.1016/j.semcancer.2020.05.008 32450139
    [Google Scholar]
  175. Lei L. Zhang J. Wei R. Dong B. Wang X. Zhou Y. Deciphering the dual role of autophagy in gastric cancer and gastroesophageal junction cancer: From tumor suppression to cancer progression. Discover Oncology 2025 16 1 1013 10.1007/s12672‑025‑02802‑x 40474010
    [Google Scholar]
  176. Murugan S. Amaravadi R.K. Methods for studying autophagy within the tumor microenvironment. Adv. Exp. Med. Biol. 2016 899 145 166 10.1007/978‑3‑319‑26666‑4_9 27325266
    [Google Scholar]
  177. Ma W. Lu Y. Jin X. Lin N. Zhang L. Song Y. Targeting selective autophagy and beyond: From underlying mechanisms to potential therapies. J. Adv. Res. 2024 65 297 327 10.1016/j.jare.2024.05.009 38750694
    [Google Scholar]
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Natural Combatants: How Herbal Monomers Regulate Autophagy in Ovarian Cancer
Bentham Science Publishers ; https://doi.org/10.2174/0118715206401652251016063228
/content/journals/acamc/10.2174/0118715206401652251016063228
/content/journals/acamc/10.2174/0118715206401652251016063228
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  • Article Type:     Review Article
Keywords: Ovarian cancer ; chemotherapy sensitivity ; gynecological malignancy ; traditional Chinese medicine monomers ; autophagy

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