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image of Anticancer Efficacy and Metabolomic Profiling of Punica granatum Leaf Extracts:

Abstract

Introduction

Current research focuses on identifying and analyzing bioactive metabolites with significant therapeutic properties derived from L. (Pomegranate) leaves. Methods: The biological potential of these metabolites was evaluated through anticancer activity. In contrast, LC-QTOF-MS and GC-QTOF-MS methods were used to profile the metabolites. molecular docking was performed using various online and offline tools to validate the active metabolites.

Results

PAC exhibited significant anticancer activity. The identified metabolites were screened, and 40 compounds from different categories were chosen for further interaction studies.

Discussion

The molecular docking analysis discovered lead molecules that exhibited promising binding energy scores, efficiency, and stable modulation with specific protein domains. However, clinical trials are required for the applications of the lead molecules in the design of anticancer drugs.

Conclusion

The findings from both and analyses support the notion that the Acetone Extract (PAC) is an excellent source of potential metabolites with therapeutic properties. According to the findings, this research enhances the treatment of human breast cancer and validates several plant traditions for their numerous benefits.

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2025-08-06
2025-09-27

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Anticancer Efficacy and Metabolomic Profiling of Punica granatum Leaf Extracts:
Bentham Science Publishers ; https://doi.org/10.2174/0118715206374500250728064151
/content/journals/acamc/10.2174/0118715206374500250728064151
/content/journals/acamc/10.2174/0118715206374500250728064151
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  • Article Type:     Research Article
Keywords: drug analysis ; anticancer activity ; phytochemistry ; metabolite profiling ; Punica granatum ; molecular docking

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