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Abstract

Tumor-infiltrating immune cells (TIICs) have been identified as critical components in the development of cancer drug resistance. This review aims to discuss the various types of TIICs, such as macrophages and T cells, that have been linked to cancer drug resistance. Furthermore, we explore the mechanisms by which TIICs contribute to drug resistance and how these mechanisms may differ across various tumor types. Additionally, we examine the potential of immune checkpoint inhibitors in combination with traditional cancer therapies as a strategy to overcome TIIC-mediated cancer drug resistance. In conclusion, this review provides an in-depth analysis of the current knowledge on the role of TIICs in cancer drug resistance and highlights potential avenues for future research to develop more effective treatment strategies. The findings presented in this review emphasize the importance of understanding the complex interactions between cancer cells and the immune system in order to develop novel therapeutic approaches that can overcome TIIC-mediated cancer drug resistance.

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2025-03-24
2025-09-26

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Unraveling the Role of Tumor-infiltrating Immune Cells in Modulating Cancer Drug Resistance
Bentham Science Publishers ; https://doi.org/10.2174/0118715206365310250310081445
/content/journals/acamc/10.2174/0118715206365310250310081445
/content/journals/acamc/10.2174/0118715206365310250310081445
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  • Article Type:     Review Article
Keywords: tumor microenvironment ; cancer drug resistance ; macrophages ; Tumor-infiltrating immune cells ; immune cell modulation ; myeloid-derived suppressor cells (MDSCs)

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