Asymmetric Synthesis: A Boom to Medicinal Chemistry
- Authors: Vishaka Chauhan1, Shubhika Goyal2, Chinmay3, Anjaneyulu Bendi4
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View Affiliations Hide Affiliations1 Department of Chemistry, Faculty of Applied and Basic Sciences, SGT University, Gurugram122001, Haryana, India 2 Department of Chemistry, Faculty of Applied and Basic Sciences, SGT University, Gurugram122001, Haryana, India 3 Department of Chemistry, Faculty of Applied and Basic Sciences, SGT University, Gurugram122001, Haryana, India 4 Department of Chemistry, Kalinga University, Kotni, Near Mantralaya, New Raipur 492101, Chhattisgarh, India
- Source: The Role of Asymmetric Synthesis in Drug Discovery , pp 1-25
- Publication Date: December 2025
- Language: English
Asymmetric Synthesis: A Boom to Medicinal Chemistry, Page 1 of 1
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Asymmetric synthesis is a foundational aspect of medicinal chemistry, offering essential insights into developing chiral molecules with high enantioselectivity. This chapter thoroughly introduces the basic principles of enantioselective synthesis, underscoring its critical importance in drug discovery and development. The ability to selectively produce single enantiomers is vital, given that the biological activity of many pharmaceutical agents is closely tied to their chirality and exploring the advantages of utilizing asymmetric synthesis, such as improved drug efficacy and reduced side effects, which are vital to advancing personalized medicine. The chapter also highlights the biological significance of chiral heterocycles, focusing on chiral amines and other compounds, and presents detailed examples of their synthetic schemes. By examining these aspects, the chapter illustrates how asymmetric synthesis facilitates the creation of more effective drugs and contributes to the ongoing innovation in medicinal chemistry.
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