Schistosomiasis: State of the Art and New Perspectives
- Authors: Salma Darwish1, Mohamed Teleb2, Sherine N. Khattab3, Adnan A. Bekhit4
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View Affiliations Hide Affiliations1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt 2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt 3 Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21321, Egypt 4 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt
- Source: Advances in the Medicinal Chemistry of Neglected Tropical Disease and Related Infectious Diseases , pp 149-186
- Publication Date: August 2025
- Language: English
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Schistosomiasis, a neglected tropical disease, affects millions worldwide. Treatment and control strategies rely entirely on the single drug praziquantel (PZQ), making the prospect of resistance emergence worrisome. The pressing need to introduce new antischistosomal agents necessitates exploring and repurposing chemotherapeutic history besides designing novel leads. In this context, this chapter summarizes the parasite life cycle, its clinical manifestations, and the progress in schistosomiasis chemotherapy with an overview of the validated drug targets, the emergence of drug resistance, and vaccination trials.
Hardbound ISBN:
9789815324792
Ebook ISBN:
9789815324785
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