Gut Microbial Metabolites as Diagnostic Biomarkers

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Metabolites that originate from the human host and microbiota significantly alter host physiology and metabolism, which is a key factor in disease susceptibility and development. The gastrointestinal tract's gut microbiota, a community of bacteria, produces vital signalling metabolites that are essential to the hosts' physiological wellbeing. However, disruptions in the production of these metabolites can result in a variety of diseases, including cancer, neurological diseases, gastrointestinal disorders, metabolic diseases, and cardiovascular diseases. The understanding of gut microbiota metabolites, encompasses their various forms and mechanisms of action on targets. Furthermore, we enumerate their physiological and pathologic roles in both health and illness, including influencing the gut microbiota's composition and providing nourishment. In order to fight microbial-driven disorders and promote health, this study can be useful in understanding the roles of gut microbiota metabolites as it provides suggestions for designing appropriate therapeutic options. Many of these metabolites may be used in conjunction with intestinal microbiota dysbiosis as diagnostic biomarkers to track disease states.