Natural Products and their Bioactive Compounds for the Prevention and Treatment of Diabetes Mellitus: A Systematic Review

- Authors: P. Chandrasekaran1, V. V. Sathibabu Uddandrao2, Parim Brahma Naidu3, Umesh Kumar4
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View Affiliations Hide Affiliations1 Centre for Biological Sciences, Department of Biochemistry, K.S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode, Namakkal District, Tamil Nadu 637215, India 2 Centre for Biological Sciences, Department of Biochemistry, K.S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode, Namakkal District, Tamil Nadu-637215, India 3 Animal Physiology and Biochemistry Laboratory, ICMR-National Animal Resource Facility for Biomedical Research (ICMR-NARFBR), Hyderabad, 500078, India 4 Department of Biosciences, Institute of Management Studies Ghaziabad (University Courses Campus), Ghaziabad, Uttar Pradesh, 201015, India
- Source: Therapeutic Plants: Recent Advances in the Use of Herbs as Alternative Medications , pp 65-83
- Publication Date: May 2025
- Language: English


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Diabetes mellitus is a long-term condition characterized by increased blood glucose levels, frequently referred to as hyperglycemia, and irregular protein and fat metabolism. Patients have an increased risk of major health issues in the future, particularly cardiovascular issues, due to the disease's chronic metabolic imbalance. DM treatment with the use of phytotherapy has a promising future since it has attained solid clinical practice. Numerous synthetic medications are used to treat the disease; however, due to their drawbacks and adverse effects, attention is being given to the use of plants and plant components in the creation of herbal remedies. A significant section of the world's population has been encouraged to switch to this alternative form of medication by the accessibility, cost, and little side effects associated with the use of herbal remedies. Since the beginning of time, plants have been the source of numerous goods for human welfare. The most beneficial antidiabetic chemicals from edible mushrooms and medicinal plants that are accessible through a variety of literature sources and databases are reviewed in this review.
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