Ionic Liquid Assisted Cross-Coupling Reactions: Recent Advances and Challenges
- Authors: Ajeet Kumar1, Vineet Jakhar2, Debabrata Konar3, Nidhi Kalia4, Archa Gulati5
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View Affiliations Hide Affiliations1 Department of Chemistry, University of Florida, Gainesville, FL, USA 2 Department of Chemistry, University of Florida, Gainesville, FL, USA 3 Department of Chemistry, University of Florida, Gainesville, FL, USA 4 Department of Chemistry, University of Florida, Gainesville, FL, USA 5 Department of Chemistry, Ramjas College, University of Delhi, Delhi 110007, India
- Source: Ionic Liquids for Organic Synthesis , pp 44-71
- Publication Date: April 2025
- Language: English
Ionic Liquid Assisted Cross-Coupling Reactions: Recent Advances and Challenges, Page 1 of 1
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Ionic liquids (ILs) are of sustained interest in synthetic organic chemistry due to their unique properties. The unique properties involve high thermal stability and ionic conductivity, and tunable solvation properties due to tunable cationic and anionic counterparts. There are a variety of cross-coupling reactions present in organic chemistry, which facilitate new carbon-carbon and carbon-heteroatom bond formation. Ionic liquids play various crucial roles in cross-coupling reactions. First, ILs are a greener alternative to flammable and hazardous volatile organic solvents (VOCs). Second, ILs are used as co-solvent in cross-coupling reactions to enhance the solubility of organometallic reagents. Third, ILs are used as the precursors of N-heterocyclic carbene (NHC) ligands that find their excellent utility in homogenous catalysis. The NHCs are an excellent alternative to air-sensitive tertiary phosphine ligands and serve as ligands for several palladium-catalyzed cross-coupling reactions. Apart from this, ILs are exploited as additives to stabilize palladium nanoparticles (Pd-NPs) in many cross-coupling reactions. This chapter outlines recent progress in key metal-catalyzed cross-coupling reactions, employing ionic liquids in diverse capacities.
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