Evaluation of Anti-aflatoxicosis Potential of Solanum americanum Mill. An Important Traditional Medicinal Plant
- Authors: N. Yogananth1, R. Selvi2, M. Syed Ali3, Velmurugan Devadasan4, Anantha Krishnan Dhanabalan5, R. Muthezhilan6
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View Affiliations Hide Affiliations1 PG and Research Department of Biotechnology, Mohamed Sathak College of Arts and Science, Sholinganallur, Chennai 600119, Tamil Nadu, India 2 Research and Evaluation, Bharathiar University, Coimbatore, Tamil Nadu, India 3 PG and Research Department of Biotechnology, Mohamed Sathak College of Arts and Science, Sholinganallur, Chennai-600119, Tamil Nadu, India 4 Department of Biotechnology, School of Bioengineering, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur-603203, Chengalpet Dt., Tamil Nadu, India 5 Department of Biotechnology, School of Bioengineering, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur-603203, Chengalpet Dt., Tamil Nadu, India 6 Department of Marine Biotechnology, AMET University, Chennai-603112, India
- Source: Herbs for Disease Prevention and Treatment , pp 125-147
- Publication Date: November 2024
- Language: English
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The contamination of aflatoxin (AF) in animal diets manifests harmful effects on animal health and productivity. The effect of ethanolic leaf extracts of Solanum americanum in rat diet against aflatoxicosis has been discussed. All hematological and biochemical parameters of AF-alone treated rats were significantly changed when compared to normal diet-treated ones. The obtained results indicated that the administration of the leaf extract of S. americanum to aflatoxicated rats improved the hematological and biochemical parameters toward their respective normal value. Molecular docking studies have been undertaken for the phytoconstituents reported for this plant against two cancers and inflammation-related protein targets. The results of this study indicated that S. americanum has the possibility of serving as an easily obtainable natural antiaflatoxigenic source for food supplements or the pharmaceutical sector.
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