A Way to Treat Kidney Diseases with Plants in Humans

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Traditional medical systems are evolving through technological advancements, with numerous scientific experiments in genomics, proteomics, transcriptomics, and pathway analysis driving discoveries in health-related issues. The primary physiological role of the kidney is the elimination of metabolic waste products and the regulation of homeostasis within the body. Renal dysfunction, characterized by the impairment of these vital functions, precipitates severe complications. Dialysis serves as a therapeutic intervention to ameliorate renal failure by effectively extricating waste products and surplus fluids from the bloodstream. Though dialysis helps in treating renal failure, it cannot cure it completely. Although synthetic drugs are not fully successful, the old medicinal system offers new paths for scientific investigations. The herbs Aerva lanata and Aerva javanica have a plethora of information about folkloric traditions and traditional characteristics of therapeutically relevant medications. The genes responsible for kidney failure are collected from NCBI and GEO databases. The network is constructed using STRING, and hub genes are identified from Cytoscape. These hub genes show valid interaction with compounds of A. lanata and A. javanica herbs than the synthetic compounds that are used in treating kidney failure. Further, the gene expression, survival and pathways are analyzed, and experiments are carried out for clinical trials. There are still numerous opportunities for researchers, practitioners, and professionals in this sector to preserve conventional healthcare systems and contribute to their future growth.