Gastroretentive Drug Delivery Systems

Preview this chapter:

Gastroretentive Drug Delivery Systems, Page 1 of 1

< Previous page | Next page > /docserver/preview/fulltext/9789815274165/chapter-6-1.gif

Administration through the oral route is the most accessible and preferred due to its many advantages. Most of the drugs administered orally show poor bioavailability due to less residing time at the gastric absorption site. To boost the bioavailability of such drugs, it is important to extend the residing time of the drug in the upper GIT, which can be achieved by using gastroretentive drug delivery systems (GRDDS). There are multiple conventional and advanced gastroretentive systems based on various mechanisms, namely high-density systems, floating systems, magnetic systems, mucoadhesive systems, expandable systems, raft-forming systems, and many more. Novel techniques like 3D printing technology are also an emerging approach in the fabrication of GRDDS. Various in vitro and in vivo techniques are used for the analysis of GRDDS, like buoyancy time, gastroscopy, scintigraphy, ultrasonography, etc. This chapter is the comprehensive literature exploring GRDDS, including various principles in the fabrication of GRDDS, techniques of preparation of GRDDS, polymers used in the fabrication of GRDDS, evaluation of GRDDS, application of 3D printing in GRDDS, and patent scenario.