Pharmacology of Andrographolide and its Analogs: An Update
- Authors: Vinod K. Nelson1, Vinyas Mayasa2, Lakshman Kumar Dogiparthi3, Panga Shyam4, Suryavanshu Roshini5, Kona Karunya6, Kola Venu7, Vijetha Pendyala8, Amit Upadhyay9, Naveen Sharma10, Jamal Basha Dudekula11, Ravishankar Ram Mani12, Kranthi Kumar Kotha13
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View Affiliations Hide Affiliations1 Centre for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai 602105, Tamil Nadu, India 2 Department of Pharmacology, GITAM School of Pharmacy, Gandhi Institute of Technology and Management Deemed to be University, Hyderabad, Telangana, India 3 Department of Pharmacognosy, MB School of Pharmaceutical Sciences, Mohan Babu University, Tirupati, Andhra Pradesh, India 4 Seva Shikshan Prasarak Mandal's Dr. N.J. Paulbudhe College of Pharmacy, Vasant Tekadi, Savedi, Ahmed Nagar, Maharashtra, India 5 Seva Shikshan Prasarak Mandal's Dr. N.J. Paulbudhe College of Pharmacy, Vasant Tekadi, Savedi, Ahmed Nagar, Maharashtra, India 6 Department of Pharmacology, Bojjam Narasimhulu College of Pharmacy, Saidabad, Hyderabad, India 7 Seva Shikshan Prasarak Mandal's Dr. N.J. Paulbudhe College of Pharmacy, Vasant Tekadi, Savedi, Ahmed Nagar, Maharashtra, India 8 Department of Pharmacognosy and Phytochemistry, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, Pradesh, India 9 Amity Institute of Pharmacy, Amity University Gwalior, Madhya Pradesh 474005, India 10 Amity Institute of Pharmacy, Amity University Gwalior, Madhya Pradesh 474005, India 11 Amity Institute of Pharmacy, Amity University Gwalior, Madhya Pradesh 474005, India 12 Faculty of Pharmaceutical Sciences, UCSI University, Cheras, Kuala Lumpur 56000, Malaysia 13 Departement of Pharmaceutics, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, Karnataka 560078, India
- Source: Andrographolide and its Analogs: Botanical Sources, Phytochemistry, Pharmacology, and Biotechnology , pp 79-96
- Publication Date: December 2024
- Language: English
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Andrographis paniculata (AP) is a traditional herb known as "king of bitters" and belongs to Acanthaceae. This plant is used traditionally to treat fever, sore throat, snake bites, and upper respiratory tract infections. The pharmacological effects exhibited by AP are actually due to the presence of several classes of phytocompounds. Among the numerous bioactive compounds generated by Androgrpahis paniculata, Andrographolide (AG) is the primary active phytochemical. This compound shows various biological functions, such as anti-inflammatory, anticancer, antimicrobial, neuroprotective, cardioprotective, and organ- and bone-protective activities. On the other hand, AG's structural analogs also showed various potent biological effects against different kinds of dreadful diseases. Hence, it is noteworthy to summarize the various pharmacological effects of AG and its analogs to help the researchers focus on this area. Therefore, in this chapter, we elaborated on various biological functions of AG and its derivatives; this review would be a standalone reference for AG's bioactives and analogs.
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