Anticancer Potential of Andrographolide and its Analogs in Colorectal Cancer: An Update
- Authors: Sunkara Surya Lakshmi1, Geetha Birudala2, Beda Durga Prasad3, Praveen Kumar Kusuma4, Moturi Anvesh Raj5, Kranthi Kumar Kotha6, Shaik Shakir Basha7, Vinyas Mayasa8, Sandeep Kanna9, Vinod K. Nelson10
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View Affiliations Hide Affiliations1 Srinivasarao College of Pharmacy, Visakhapatnam, Andhra Pradesh 530041, India 2 Faculty of Pharmacy, Dr. M.G.R. Educational and Research Institute, Velappanchavadi, Chennai, India 3 Department of Pharmaceutical Chemistry, GITAM School of Pharmacy, Hyderabad, Telangana, Indiai 4 Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Govt. of NCT of Delhi, Delhi Pharmaceutical Sciences and Research University (DPSRU), Mehrauli-Badarpur Road, India 5 JSS Academy of Higher Education & Research, Rocklands, Ooty, Nilgiris, Tamil Nadu-643001, India 6 Departement of. Pharmaceutics, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, Karnataka 560078, India 7 Centre for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai 602105, Tamil Nadu, India 8 Department of Pharmacology, GITAM School of Pharmacy, Gandhi Institute of Technology and Management Deemed to be University, Hyderabad, Telangana, India 9 Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam - 522034, India 10 Centre for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai 602105, Tamil Nadu, India
- Source: Andrographolide and its Analogs: Botanical Sources, Phytochemistry, Pharmacology, and Biotechnology , pp 201-217
- Publication Date: December 2024
- Language: English
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Colorectal cancer (CRC) is a highly prevalent and leading cause of death globally. Though well-developed treatment strategies are available, colorectal cancer is still a challenging health problem in developed and developing countries. Despite advanced treatment methods, all may not exterminate the tumor since most cases of CRCs are diagnosed at the last stage, and treatment-associated drug toxicity and resistance are major concerns. Therefore, it is imperative to discover anticancer drugs with less toxicity and no drug resistance. During the process of new drug discovery, medicinal plants and their derivatives play a significant role. This chapter/review explores andrographolides and their derivatives as potential anticancer drug candidates to combat colorectal cancer. This chapter describes the molecular mechanisms of colorectal cancer, potential drug targets in cancer, the anticancer potential of andrographolide derivatives in various malignancies, and its specific function in preventing CRC. This review provides concise information and possible clues for researchers to develop andrographolides, their derivatives and anticancer drugs to treat colorectal cancer.
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