Pharmacology in Geriatric Anesthesia
- Authors: Reuben DSouza1, George Hsu2
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View Affiliations Hide Affiliations1 Department of Anesthesiology, Cooper Medical School of Rowan University, Cooper University Health Care, Camden, NJ, USA 2 Department of Anesthesiology, Cooper Medical School of Rowan University, Cooper University Health Care, Camden, NJ, USA
- Source: Geriatric Anesthesia: A Practical Guide , pp 23-40
- Publication Date: April 2024
- Language: English
Pharmacology in Geriatric Anesthesia, Page 1 of 1
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In terms of different pharmacokinetic and pharmacodynamic interactions, geriatric patients exhibit greater sensitivity to anesthetics. Therefore, understanding the differences in body composition, hepatic and renal function, changes in protein binding, and minimal alveolar concentration are the key to titration of anesthetics in geriatric patients. In addition, polypharmacy, use of non-prescription medications and adverse medications related events warrant special considerations for the geriatric population, more so than in their younger counterparts. Lastly, careful titration of anesthetics may minimize the development of postoperative delirium and postoperative cognitive dysfunction, which are associated with higher morbidity, mortality, length of hospitalization, and overall cost.
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