Large-Scale Organoid Culture for High Throughput Drug Screening
- Authors: Shraddha Gautam1, Atul Kumar Singh2, Sachin Kadam3
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View Affiliations Hide Affiliations1 Advancells Group, A 102, Sector 5, NOIDA, Uttar Pradesh 201301, India 2 Central Research Facility, IIT Delhi Sonipat Campus, Rajiv Gandhi Education City, Sonipat, Haryana 131029, India 3 Manipal Center for Biotherapeutics Research, Manipal Academy of Higher Education (Institute of Eminence Deemed to be University), Manipal 576104, India
- Source: Organoid Technology: Disease Modelling, Drug Discovery, and Personalized Medicine , pp 257-276
- Publication Date: July 2025
- Language: English
Large-Scale Organoid Culture for High Throughput Drug Screening, Page 1 of 1
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Despite several limitations, two-dimensional cell culture has been widely used in drug and drug-related compound selection and screening studies. A more recent approach of using three-dimensional (3D) organoid culture enables researchers with a more robust and accurate model for drug screening. Numerous studies have reported the successful use of stem cells, including induced pluripotent stem cells (iPSCs) and adult stem cells, for organoid generation to predict therapy response in various disease conditions, including cancer. The development of high-throughput drug screening and organoids-on-a-chip technology can advance the use of patient-derived organoids in clinical practice and facilitate therapeutic decision-making. Although organoids are in complaisant with high-throughput screenings, extensive manipulation studies are required by current methods.
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