Vitamin D and Immune System: Implications in Bone Health
- Authors: Asha Bhardwaj1, Tamanna Sharma2, Sneha Das3, Leena Sapra4, Rupesh K. Srivastava5
-
View Affiliations Hide Affiliations1 Translational Immunology, Osteoimmunology & Immunoporosis Lab (TIOIL), Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi 110029, India 2 Translational Immunology, Osteoimmunology & Immunoporosis Lab (TIOIL), Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi-110029, India 3 Translational Immunology, Osteoimmunology & Immunoporosis Lab (TIOIL), Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi-110029, India 4 Translational Immunology, Osteoimmunology & Immunoporosis Lab (TIOIL), Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi-110029, India 5 Translational Immunology, Osteoimmunology & Immunoporosis Lab (TIOIL), Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi-110029, India
- Source: Osteoporosis, Osteoarthritis and Rheumatoid Arthritis: An Agonizing Skeletal Triad , pp 46-74
- Publication Date: November 2023
- Language: English
Vitamin D and Immune System: Implications in Bone Health, Page 1 of 1
< Previous page | Next page > /docserver/preview/fulltext/9789815196085/chap4-1.gif
Recent studies have identified the involvement of the immune system in several bone complications like osteoporosis, rheumatoid arthritis (RA), periodontitis, osteoarthritis, etc. Immune cells have an indispensable role in the regulation of bone metabolism and explicitly influence the differentiation of bone cells by producing various cytokines. Fortunately, recent research has examined different immune-based therapeutics for the prevention of bone diseases in addition to revealing more information about the interaction of the bone and the immune system. Vitamin D maintains bone health by effectively absorbing calcium and thereby promoting bone mineralization. In addition, vitamin D has great immunomodulatory potential and can influence the effect of immune cells and cytokines on the pathogenesis of bone deformities. Therefore, it is plausible to suggest that the detrimental effect of vitamin D deficiency on bone is also linked to the immune system apart from its classic effect on bone mineralization. However, very few studies have enlightened on this aspect of vitamin D-mediated regulation of bone homeostasis which needs to be further unraveled. In the present chapter, we have compiled recent studies highlighting the effect of vitamin D on bone health via its effect on the host immune system. Further, we have also highlighted the role of the immune system in the maintenance of skeletal health and then have discussed the effect of vitamin D on various immune cells. In addition, we have reviewed vitamin D-facilitated immune-based approaches for the effective management of various bone pathologies such as osteoporosis, osteoarthritis and rheumatoid arthritis. This information will supposedly help in revealing further mechanistic insights into the immunological regulation of bone health by vitamin D.
-
From This Site
/content/books/9789815196085.chap4dcterms_subject,pub_keyword-contentType:Journal -contentType:Figure -contentType:Table -contentType:SupplementaryData105
