The Prostanoids

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This chapter is a comprehensive account of the medicinal chemistry of drugs arising from structural modifications of prostanoids, which are naturally occurring eicosanoids. These drugs are used for a variety of diseases including but not limited to glaucoma, pulmonary arterial hypertension, and peptic ulcers. This chapter provides the mechanism of drug action and structure-activity relationships (SAR) of these drugs. After studying this chapter, students will be able to: • Describe the historical background of prostanoids as clinical agents. • Explain the structure, functions, classifications and biosynthesis of eicosanoids. • Discuss in detail the chemistry and SAR of the prostanoids involved in the treatment of glaucoma, pulmonary arterial hypertension, peptic ulcer, and other diseases.• Delineate the clinical significance and therapeutic evaluations of these classes of drugs by solving case studies. • Explain the discovery process of latanoprost and zafirlukast.