Photodynamic Therapy and Applications in Cancer
- Authors: Ceren Sarı1, Figen Celep Eyüpoğlu2
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View Affiliations Hide Affiliations1 Department of Medical Biology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey 2 Department of Medical Biology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
- Source: Recent Progress in Pharmaceutical Nanobiotechnology: A Medical Perspective , pp 81-116
- Publication Date: December 2023
- Language: English
Photodynamic Therapy and Applications in Cancer, Page 1 of 1
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The idea of using light as a therapeutic tool has been popular for thousands of years. Scientific discoveries in line with technological innovations have contributed to the advancement of photodynamic therapy as a therapeutic modality. Photodynamic therapy is based on the generation of highly reactive species that alter the molecular systematics of cells through interactions between light, photosensitizer, and molecular oxygen. It has a minimally invasive protocol that can be combined with other clinical methods or can be stand-alone. The development of photosensitizers with the integration of nanotechnological approaches has provided favorable results over the years in malignant and non-malignant diseases by facilitating target-site action, selectivity, and controllable drug release. This chapter presents a review of photodynamic therapy with its important aspects; history, mechanism of action, cellular effects, integration into nanoscale drug delivery systems, and combinational therapeutic approaches in cancer.
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