TMP21 in Alzheimers Disease: An Important Target For Effective Treatment Approach
- Authors: Dipanjan Karati1, Dileep Kumar2
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View Affiliations Hide Affiliations1 Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharti Vidyapeeth, Pune, 411038 India 2 Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharti Vidyapeeth, Pune, 411038 India
- Source: Enzymatic Targets for Drug Discovery Against Alzheimer's Disease , pp 73-92
- Publication Date: December 2023
- Language: English
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Alzheimer's disease (AD) is the most prevalent form of dementia, and it is considered a dynamic cognitive decline. Neurofibrillary tangles and nerve cell injury are important neuropharmacological symptoms for one AD brain. TMP21 is an important molecule in cellular protein trafficking. TMP21, a protein involved in the production of neurotic plaques, appears to be dysregulated in AD. As a result, we want to look into TMP21 dysregulation in Alzheimer's disease, as well as the involvement of TMP21 in neurotic plaque development and the underlying mechanisms. TMP21's significance in the creation of neurofibrillary tangles, synaptic disbalance, and nerve cell death is also explored. It will shed light on the therapeutic potential of regulating TMP21 as a treatment for AD.<br>
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