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Intellectual Disabilities

- Authors: Zafar Ali1, Uzma Abdullah2, Ambrin Fatima3
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View Affiliations Hide Affiliations1 Centre for Biotechnology and Microbiology, University of Swat, Swat19130, Pakistan 2 University Institute of Biochemistry and Biotechnology (UIBB), PMAS Arid Agriculture University, Rawalpindi. Pakistan 3 Department of Biological and Biomedical Sciences. The Aga Khan University, Karachi, Pakistan
- Source: Omics Technologies for Clinical Diagnosis and Gene Therapy: Medical Applications in Human Genetics , pp 269-282
- Publication Date: October 2022
- Language: English
Intellectual disability (ID) is caused by the disruption of neurodevelopmental processes. Its diagnosis and severity are defined in terms of an Intelligence Quotient score of lt;70. ID has diverse presentations and clinical overlaps with other cognitive disorders such as autism spectrum disorder and microcephaly. ID has a diverse etiology encompassing both environmental and genetic insults to the developing brain. The precise diagnosis is challenging but crucial for prognosis and risk assessment for future pregnancies. The suspected cases of genetic ID often follow a strategic series of tests for diagnosis. There is no effective cure for this disorder except in the cases of early diagnosed metabolic disorders. The available therapies are mostly aimed at easing the symptoms and improving the quality of life.
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