Saponins in the Treatment of Gastrointestinal Tract Cancer
- Authors: Zunera Chauhdary1, Muhammad Ajmal Shah2, Malik Hassan Mehmood3, Uzma Saleem4, Azhar Rasul5, Ghulam Mujtaba Shah6, Ajmal Khan7, Ahmed Al Harrasi8, Shabnoor Iqbal9, Shabana Bibi10
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View Affiliations Hide Affiliations1 Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan 2 Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan 3 Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, Pakistan 4 Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan 5 Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, Pakistan 6 Department of Botany, Hazara University, Mansehra, Pakistan 7 Natural and Medical Sciences Research Centre, University of Nizwa, PO Box 33, 616 Birkat Al Mauz, Nizwa, Oman 8 Natural and Medical Sciences Research Centre, University of Nizwa, PO Box 33, 616 Birkat Al Mauz, Nizwa, Oman 9 Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, Pakistan 10 Yunnan Herbal Laboratory, School of Ecology and Environmental Sciences, Yunnan University, Kunming 650091, Yunnan, China
- Source: Phytonutrients in the Treatment of Gastrointestinal Cancer , pp 159-181
- Publication Date: May 2023
- Language: English
Saponins in the Treatment of Gastrointestinal Tract Cancer, Page 1 of 1
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The natural glycosides with triterpenoid or spirostaneaglycones are the saponins, which are associated with a wide range of therapeutic activities, inclusive of gastrointestinal anticancer activities. To promote research and development of novel cytotoxic agents against GIT cancer, this chapter focused on the anticancer potentia l of the naturally occurring triterpenoid and steroidal saponins. The in vitro assays and in vivo studies authenticated the anticancer potential of these compounds through anti-angiogenic, anti-proliferative, anti-metastatic and anti-multidrug resistance activities. The protein targets and signaling cascades behind the anticancer effect of these compounds in GIT cancer are also discussed in this chapter. nbsp;
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