Free Radical Biology of Diabetes Mellitus
- Authors: Bidita Khandelwal1, Chamma Gupta2, Levin Thomas3, Sonal Sekhar Miraj4, Mahadev Rao5, Rubi Dey6, Karma Gurmey Dolma7, Rinchen Doma Bhutia8, Vijay Pratap Singh9
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View Affiliations Hide Affiliations1 Department of Medicine, Sikkim Manipal Institute of Medical Sciences, Sikkim ManipalUniversity, Gangtok, Sikkim 737102, India 2 Department of Biochemistry, Sikkim Manipal Institute of Medical Sciences, Sikkim ManipalUniversity, Gangtok, Sikkim-737102, India 3 Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, ManipalAcademy of Higher Education, Manipal, Karnataka-576104, India 4 Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, ManipalAcademy of Higher Education, Manipal, Karnataka-576104, India 5 Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, ManipalAcademy of Higher Education, Manipal, Karnataka-576104, India 6 Department of Physiology, Sikkim Manipal Institute of Medical Sciences, Sikkim ManipalUniversity, Gangtok, Sikkim-737102, India 7 Department of Microbiology, Sikkim Manipal Institute of Medical Sciences, Sikkim ManipalUniversity, Gangtok, Sikkim-737102, India 8 Department of Biochemistry, Sikkim Manipal Institute of Medical Sciences, Sikkim ManipalUniversity, Gangtok, Sikkim-737102, India 9 Department of Physiotherapy, Kasturba Medical College, Manipal Academy of HigherEducation, Manipal, 576104 India
- Source: Free Radical Biology of Endocrine, Metabolic and Immune Disorders , pp 1-40
- Publication Date: April 2022
- Language: English
Free Radical Biology of Diabetes Mellitus, Page 1 of 1
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Free radicals play a pivotal role in the etiology of different diseases, including diabetes mellitus (DM). In the past three decades, the understanding of the fundamental role of free radicals in the etiology and disease progression of DM was studied broadly. This chapter aimed to enumerate the recent progress in the areas of free radical biology for the management of DM. Free radicals, as well as reactive oxygen species (ROS), having extra electrons in their outer orbitals, react with all biomolecules, including “protein, lipids, and DNA,” causing oxidative stress and damage. DM is also associated with oxidative stress induced by the elevated production of free radicals or reduced antioxidant activity. Recently, the importance of an antioxidant rich diet, yoga, and exercise has been well documented for the management of DM. Studies confirmed that exercise-induced ROS is an acute effect, while the chronic effect of exercise produces endogenous antioxidant defences and promotes a state of endogenous antioxidant defence mechanism. Therefore, regulating oxidative stress will lead to a significant future area of research for DM disease management.
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