Endocrine Role of Osteocalcin in Homeostatic Regulation of Glucose Metabolism
- Authors: Madhu Gupta1, Md. Arshad2, Rahul Gupta3
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View Affiliations Hide Affiliations1 Department of Zoology, University of Lucknow, Lucknow 226007, U.P., India 2 Department of Zoology, Aligarh Muslim University, Aligarh-202002, U.P., India 3 Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus, Lucknow-226028, U.P., India
- Source: Pharmacological and Molecular Perspectives on Diabetes , pp 38-53
- Publication Date: April 2022
- Language: English
Endocrine Role of Osteocalcin in Homeostatic Regulation of Glucose Metabolism, Page 1 of 1
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nbsp;Osteocalcin, a well-known bone formation marker, is secreted from osteoblasts and exists in fully carboxylated, partially carboxylated, and completely uncarboxylated forms. The endocrine involvement of uncarboxylated osteocalcin in glucose homeostasis has recently been confirmed. It has been demonstrated that double recessive osteocalcin mutant mice are hyperglycemic, hypoinsulinemic, and have reduced β cell numbers and insulin resistance. In contrast, leptin (an adipocyte-derived hormone) indirectly regulates the secretion of insulin in part through inhibition of osteocalcin conversion to uncarboxylated form via β2 adrenergic receptor signaling in osteoblasts. Because uncarboxylated osteocalcin is a secretagogue of insulin, which in turn positively regulates the bone formation, osteocalcin lies at the centre of the complex mechanism of glucose homeostasis and bone remodeling network.
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