Heterocyclic Anti-cancer Compounds Derived from Natural Sources with their Mechanism of Action
- Authors: Sitesh C. Bachar1, A.K.M. Shafiul Kadir2, S.M. Riajul Wahab3, Abdullah Al Hasan4
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View Affiliations Hide Affiliations1 Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh 2 Institute of Biological Sciences (IBSc), University of Rajshahi, Bangladesh 3 School of Pharmacy, The University of Texas at El Paso, Texas, USA 4 Department of Pharmacy, Southeast University, Dhaka, Bangladesh
- Source: Key Heterocyclic Cores for Smart Anticancer Drug–Design Part I , pp 1-56
- Publication Date: July 2022
- Language: English
Heterocyclic Anti-cancer Compounds Derived from Natural Sources with their Mechanism of Action, Page 1 of 1
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The variety of natural compounds is indispensable due to their mechanism of action. For many years, natural compounds have been used to develop new classes of chemotherapeutic agents. Chemotherapeutic agents derived and synthesised from natural sources could be the best possible alternatives to minimise the harmful after effects of conventionally used agents against cancer, especially oral and maxillofacial carcinoma and tumors. The proposed chapter concentrates on recent research on various classes of natural scaffolds and their analogues that possess potent antitumor activity. Moreover, we would like to provide an analysis of preclinical and/or clinically investigated natural compounds. These compounds and their synthetic heterocyclic analogues were found to be obtained through bioactivity and mechanism of action directed isolation and characterization, conjoined with modification using rational drug design-based approaches and analogue synthesis. Structure-activity relationships, structural change, and molecular mechanisms of action will all be examined.
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