Haematological Modulations by Fixed Dose Combination (FDC) of Tramadol Hydrochloride/Paracetamol (THP)

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Haematological Modulations by Fixed Dose Combination (FDC) of Tramadol Hydrochloride/Paracetamol (THP), Page 1 of 1

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Analgesics as fixed-dose combination are very useful for fast pain relief.Overdose or chronic use of analgesics, especially fixed doses form, develop mild tosevere adverse effects and sometimes damage various organs like the liver, kidney andbrain. Tramadol hydrochloride/paracetamol (THP) is a fixed-dose combination (37.5mg of Tramadol hydrochloride and 325 mg of paracetamol) extensively used for thetreatment of moderate to severe pain. Administration of THP upon animal modelseverely disturbed hepatic and renal biochemical parameters, which leads to alteringnormal cellular homeostasis. In this context, our recent study established that theapplication of Tramadol hydrochloride/paracetamol produced deleterious effects onhaematological parameters in the experimental murine model. 1.12 g/300 ml and 1.68g/300 ml chronic administration of Tramadol hydrochloride/paracetamol (THP)decrease the packed cell volume (PCV), haemoglobin (Hb), mean cell volume (MCV),means cell haemoglobin (MCH) and increase the mean corpuscular haemoglobinconcentration (MCHC) and white blood cell (WBC) in an experimental animal model.Other haematological parameters likes red blood corpuscle (RBC), reticulocyte (RT),haematocrit (HCT) did not show any significant changes upon animals. IncreasedMCHC inhibits the oxidation process and energy balance, whereas elevated WBClevels indicate immune system damage. Decreased haemoglobin and PCV indicate thatTramadol hydrochloride/paracetamol (THP) is an indirect cause of anaemia. It may beconcluded that prolonged or chronic administration of THP may cause severethrombocytopenia, leading to the failure of the immune system, anemia, and a very lowerythrocyte count. These side effects increase according to the dosage and duration ofthe treatment. So clinicians, patients and pharmacists should be aware of thedeleterious effects of Tramadol hydrochloride/paracetamol (THP) on haematologicalparameters when using this combination.