Artemisinin Analogues as a Novel Class of Antimalarial Agents: Recent Developments, Current Scenario and Future Perspectives

The comprehensive chronological advancement and statistical account of the recent developments and current scenario on antimalarial chemotherapy, in particularly, based on various types of artemisinin analogues and their potential as antimalarial agents have been schematically presented in this book chapter. These studies had compared efficacies of various semi-synthetic artemisinin analogues with that of standard reference drug artemisinin, β-Arteether and various other anti-malarial drugs. Thus, this book chapter highlights the recent advancements and historical developments observed in the medicinal chemistry of artemisinin since its discovery during the past 49 years (1971-2020). Hence, this book chapter will serve as first-hand information on artemisinin-based antimalarial peroxides to organic and medicinal chemists, as well as biologist/pharmacologists working on anti-malarial drug discovery and development.