Pharmacogenomics and Perioperative Translational Medicine
- Authors: Sirirat Rattana arpa1, Patcharee Sriswasdi2
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View Affiliations Hide Affiliations1 Department of Anesthesiology Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand 2 Department of Anesthesiology Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
- Source: Recent Advances in Molecular and Translational Medicine: Updates in Precision Medicine , pp 68-92
- Publication Date: December 2021
- Language: English
Pharmacogenomics and Perioperative Translational Medicine, Page 1 of 1
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Multiple drugs with various mechanisms of action are used simultaneously during the perioperative period. Opioids, inhalations, intravenous induction agents, neuromuscular blocking agents and sedative agents are the common drugs used. Even if the same dose of drug is administered, diverse individual responses usually occur. These various individual responses might relate to the patients pharmacogenomic variations. Thus, the genotype-phenotype relationship should be carefully considered in adults. Furthermore, developmental pharmacogenomics also plays important role in pediatric patients who have dynamic growth and development process from infants to adolescents. This review shows the pharmacogenetic aspects of these common anesthetic medications and future trends for perioperative pharmacogenomic testing.
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