Tools for Prediction and Validation of Epitopic Regions on Protein Targets for Vaccine Development and Diagnostics
- Authors: Soban Tufail1, Majid Ali Shah2, Maryam Zafar3, Mazhar Iqbal4, Amjad Ali5, Aamir Shehzad6, Moazur Rahman7
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View Affiliations Hide Affiliations1 Drug Discovery and Structural Biology Group, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan 2 Drug Discovery and Structural Biology Group, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan 3 Drug Discovery and Structural Biology Group, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan 4 Drug Discovery and Structural Biology Group, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan 5 Atta ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan 6 Drug Discovery and Structural Biology Group, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan 7 Drug Discovery and Structural Biology Group, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan
- Source: Frontiers in Molecular Pharming , pp 1-29
- Publication Date: December 2021
- Language: English
Tools for Prediction and Validation of Epitopic Regions on Protein Targets for Vaccine Development and Diagnostics, Page 1 of 1
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Epitopes are parts of an antigen that are recognized by the immune system. Identification of epitopic regions on an immunogenic protein is important for several clinical and biotechnological applications. Various bioinformatics tools are currently available which can be used for the prediction of epitopic regions, and the immune response generated against selected epitopic regions can be monitored through a variety of immunological techniques. In this chapter, we provide an overview of widely used in silico tools for the prediction of epitopic regions, followed by biophysical methods used for their characterization. Furthermore, a brief description of important immunological approaches for measuring immune responses elicited by epitopes is also given. It is anticipated that the information provided in this chapter will help researchers in selecting appropriate tools for the prediction and validation of epitopes on a protein target for vaccine development and diagnostics.
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