Synthesis and Anti-TB Activity Screening of Benzothiazole Amide Derivatives
- Authors: Mahesh Bhat1, S.L. Belagali2
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View Affiliations Hide Affiliations1 Department of Chemistry, JSS College for Women, Saraswathipuram, Mysore 09, Karnataka, India 2 Environmental Chemistry Laboratory, DOS in Environmental Science, University of Mysore, Karnataka, India
- Source: In-Silico and In-Vitro Approaches to Screen the Antituberculosis Activity of Benzothiazole Analogs , pp 66-76
- Publication Date: February 2021
- Language: English
Synthesis and Anti-TB Activity Screening of Benzothiazole Amide Derivatives, Page 1 of 1
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Synthesis of diamide derivatives are carried out by the phenylalanine initially phenylalanine reacts with the aromatic amine by the acid amine coupling followed by de-protection of the boc and further reacts with the benzothiazole carboxylic acid by the formation of the amide coupling in the presence HATU as coupling reagent. Further series of the diamide benzothiazole derivative compounds were screened for the in-silico and in-vitro anti TB activity. In in-silico method compounds show a good docking score with respect to the standard drug. In-vitro Alamar blue assay demonstrate some of the compounds marked for the superior activity with minimum inhibitory concentration 1.6 µg/mL.
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